Clinical features of individuals with laboratory values suggestive of advanced liver fibrosis when first treated for alcohol use disorder

Zuluaga, Paola; Fuster, Daniel; Blanes, Rafael; Hernández Rubio, Anna; Miquel, Laia; Torrens, Marta; Rubio, Gabriel; Bolao, Ferran; Liangpunsakul, Suthat; Abellí-Deulofeu, Enric; Rodríguez de Fonseca, Fernando; Muga, Roberto; CohRTA Study

Clinical features of individuals with laboratory values suggestive of advanced liver fibrosis when first treated for alcohol use disorder

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dc.contributor.author Zuluaga, Paola
dc.contributor.author Fuster, Daniel
dc.contributor.author Blanes, Rafael
dc.contributor.author Hernández Rubio, Anna
dc.contributor.author Miquel, Laia
dc.contributor.author Torrens, Marta
dc.contributor.author Rubio, Gabriel
dc.contributor.author Bolao, Ferran
dc.contributor.author Liangpunsakul, Suthat
dc.contributor.author Abellí-Deulofeu, Enric
dc.contributor.author Rodríguez de Fonseca, Fernando
dc.contributor.author Muga, Roberto
dc.contributor.author CohRTA Study
dc.date.accessioned 2024-09-25T05:57:57Z
dc.date.available 2024-09-25T05:57:57Z
dc.date.issued 2024
dc.description.abstract Background: Effective screening for alcohol-associated liver disease is relevant in the context of chronic, excessive alcohol consumption. Patients with alcohol-associated liver disease are often not diagnosed until their liver disease is decompensated. We analyzed the prevalence and associations of Fibrosis-4 index (FIB-4) values suggestive of advanced liver fibrosis in patients referred for their first treatment of alcohol use disorder (AUD). Methods: We conducted a cross-sectional, multicenter study of noncirrhotic individuals referred for their first AUD treatment between March 2013 and April 2021. We obtained sociodemographic data, substance use characteristics, and blood samples at admission. We considered a FIB-4 value ≥2.67 suggestive of advanced liver fibrosis and used logistic regression analyses to identify features associated with this value. Results: We included 604 patients (67% male), with a median age at admission of 48 years [IQR: 41-56 years]. The median duration of regular alcohol consumption was 21 years [IQR: 18-30 years] and the median alcohol consumption was 105 standard drink units (SDU)/week [IQR: 63-160 SDU/week]. A FIB-4 value ≥ 2.67 was present in 19.3% of cases. These patients reported more frequent binge drinking (75.4% vs. 66%, p = 0.05) than those with FIB-4 values below 2.67. In multivariate analysis, a history of binge drinking (OR 1.9, 95% CI, 1.05-3.47), anemia (OR 2.95, 95% CI, 1.42-6.11), leukopenia (OR 7.46, 95% CI, 2.07-26.8), and total serum bilirubin >1 mg/dL (OR 6.46, 95% CI, 3.57-11.7) were independently associated with FIB-4 values ≥2.67. Conclusions: One in five patients admitted to treatment for AUD without evidence of decompensated liver disease have FIB-4 values suggestive of advanced liver fibrosis. The presence of a binge drinking history, anemia, leukopenia, and elevated bilirubin levels is associated with high FIB-4 values.
dc.format.mimetype application/pdf
dc.identifier.citation Zuluaga P, Fuster D, Blanes R, Hernández-Rubio A, Miquel L, Torrens M, et al. Clinical features of individuals with laboratory values suggestive of advanced liver fibrosis when first treated for alcohol use disorder. Alcohol Clin Exp Res (Hoboken). 2024 Jul;48(7):1313-21. DOI: 10.1111/acer.15345
dc.identifier.doi http://dx.doi.org/10.1111/acer.15345
dc.identifier.issn 2993-7175
dc.identifier.uri http://hdl.handle.net/10230/61213
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Alcohol Clin Exp Res (Hoboken). 2024 Jul;48(7):1313-21
dc.rights © 2024 The Authors. Alcohol, Clinical and Experimental Research published by Wiley Periodicals LLC on behalf of Research Society on Alcohol. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword FIB‐4 index
dc.subject.keyword Advanced liver fibrosis
dc.subject.keyword Alcohol‐associated liver disease
dc.subject.keyword Binge drinking
dc.subject.keyword Leukopenia
dc.title Clinical features of individuals with laboratory values suggestive of advanced liver fibrosis when first treated for alcohol use disorder
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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