Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients

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  • dc.contributor.author Barbeta, Enric
  • dc.contributor.author Marin Corral, Judith
  • dc.contributor.author Torres, Antoni
  • dc.date.accessioned 2025-05-05T06:25:30Z
  • dc.date.available 2025-05-05T06:25:30Z
  • dc.date.issued 2025
  • dc.description.abstract Background: The relative contribution of the different components of mechanical power to mortality is a subject of debate and has not been studied in COVID-19. The aim of this study is to evaluate both the total and the relative impact of each of the components of mechanical power on mortality in a well-characterized cohort of patients with COVID-19-induced acute respiratory failure undergoing invasive mechanical ventilation. This is a secondary analysis of the CIBERESUCICOVID project, a multicenter observational cohort study including fifty Spanish intensive care units that included COVID-19 mechanically ventilated patients between February 2020 and December 2021. We examined the association between mechanical power and its components (elastic static, elastic dynamic, total elastic and resistive power) with 90-day mortality after adjusting for confounders in seven hundred ninety-nine patients with COVID-19-induced respiratory failure undergoing invasive mechanical ventilation. Results: At the initiation of mechanical ventilation, the PaO2/FiO2 ratio was 106 (78; 150), ventilatory ratio was 1.69 (1.40; 2.05), and respiratory system compliance was 35.7 (29.2; 44.5) ml/cmH2O. Mechanical power at the initiation of mechanical ventilation was 24.3 (18.9; 29.6) J/min, showing no significant changes after three days. In multivariable regression analyses, mechanical power and its components were not associated with 90-day mortality at the start of mechanical ventilation. After three days, total elastic and elastic static power were associated with higher 90-day mortality, but this relationship was also found for positive end-expiratory pressure. Conclusions: Neither mechanical power nor its components were independently associated with mortality in COVID-19-induced acute respiratory failure at the start of MV. Nevertheless, after three days, static elastic power and total elastic power were associated with lower odds of survival. Positive end-expiratory pressure and plateau pressure, however, captured this risk in a similar manner.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Barbeta E, Barreiros C, Forin E, Guzzardella A, Motos A, Fernández-Barat L, et al. Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients. Ann Intensive Care. 2025 Feb 25;15(1):27. DOI: 10.1186/s13613-025-01430-6
  • dc.identifier.doi http://dx.doi.org/10.1186/s13613-025-01430-6
  • dc.identifier.issn 2110-5820
  • dc.identifier.uri http://hdl.handle.net/10230/70283
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof Ann Intensive Care. 2025 Feb 25;15(1):27
  • dc.rights © The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword COVID-19
  • dc.subject.keyword Mechanical power
  • dc.subject.keyword Mechanical ventilation
  • dc.subject.keyword Respiratory failure
  • dc.title Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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