Changing to a low-polyphenol diet alters vascular biomarkers in healthy men after only two weeks
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- dc.contributor.author Hurtado-Barroso, Sara
- dc.contributor.author Quifer-Rada, Paola
- dc.contributor.author Rinaldi de Alvarenga, José Fernando
- dc.contributor.author Pérez-Fernández, Silvia
- dc.contributor.author Tresserra-Rimbau, Anna
- dc.contributor.author Lamuela-Raventós, Rosa M.
- dc.date.accessioned 2019-06-21T07:41:25Z
- dc.date.available 2019-06-21T07:41:25Z
- dc.date.issued 2018
- dc.description.abstract Bioactive dietary compounds play a critical role in health maintenance. The relation between bioactive compound intake and cardiovascular health-related biomarkers has been demonstrated in several studies, although mainly with participants who have altered biochemical parameters (high blood pressure, high cholesterol, metabolic syndrome, etc.). The aim of this study was to evaluate if adopting a diet low in polyphenol-rich food for two weeks would affect vascular biomarkers in healthy men. In a crossover study, 22 healthy men were randomly assigned to their usual diet (UD), consuming healthy food rich in polyphenols, or to a low antioxidant diet (LAD), with less than two servings of fruit and vegetables per day and avoiding the intake of cocoa products, coffee and tea. As a marker of compliance, total polyphenols in urine were significantly lower after the LAD than after the UD (79 ± 43 vs. 123 ± 58 mg GAE/g creatinine). Nitric oxide levels were also reduced (52 ± 28 in LAD vs. 80 ± 34 µM in UD), although no significant changes in cellular adhesion molecules and eicosanoids were observed; however, an increasing ratio between thromboxane A₂ (TXA₂) and prostaglandin I₂ (PGI₂) was reached (p = 0.048). Thus, a slight dietary modification, reducing the consumption of polyphenol-rich food, may affect vascular biomarkers even in healthy individuals.
- dc.description.sponsorship This research was funded by CYCIT from Ministerio de Ciencia, Innovación y Universidades), grant number AGL2016-79113-R and Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn).
- dc.format.mimetype application/pdf
- dc.identifier.citation Hurtado-Barroso S, Quifer-Rada P, Rinaldi de Alvarenga JF, Pérez-Fernández S, Tresserra-Rimbau A, Lamuela-Raventos RM. Changing to a low-polyphenol diet alters vascular biomarkers in healthy men after only two weeks. Nutrients. 2018 Nov 14;10(11). pii: E1766. doi: 10.3390/nu10111766
- dc.identifier.doi http://dx.doi.org/10.3390/nu10111766
- dc.identifier.issn 2072-6643
- dc.identifier.uri http://hdl.handle.net/10230/41857
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/AGL2016-79113-R
- dc.rights Copyright © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Mediterranean diet
- dc.subject.keyword Adhesion molecules
- dc.subject.keyword Bioactive compounds
- dc.subject.keyword Eicosanoids
- dc.subject.keyword Low antioxidant diet
- dc.subject.keyword Nitric oxide
- dc.subject.keyword Vascular biomarkers
- dc.title Changing to a low-polyphenol diet alters vascular biomarkers in healthy men after only two weeks
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion