Analysis of five gene sets in chimpanzees suggests decoupling between the action of selection on protein-coding and on noncoding elements
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Santpere Baró, Gabriel, 1981-ca
- dc.contributor.author Carnero-Montoro, Elena, 1985-ca
- dc.contributor.author Petit, Nataliaca
- dc.contributor.author Serra, Françoisca
- dc.contributor.author Hvilsom, Christinaca
- dc.contributor.author Rambla de Argila, Jordica
- dc.contributor.author Heredia Genestar, José María, 1985-ca
- dc.contributor.author Halligan, Daniel L.ca
- dc.contributor.author Dopazo, Hernánca
- dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-ca
- dc.contributor.author Bosch Fusté, Elenaca
- dc.date.accessioned 2015-11-12T14:47:18Z
- dc.date.available 2015-11-12T14:47:18Z
- dc.date.issued 2015
- dc.description.abstract We set out to investigate potential differences and similarities between the selective forces acting upon the coding and noncoding regions of five different sets of genes defined according to functional and evolutionary criteria: 1) two reference gene sets presenting accelerated and slow rates of protein evolution (the Complement and Actin pathways); 2) a set of genes with evidence of accelerated evolution in at least one of their introns; and 3) two gene sets related to neurological function (Parkinson's and Alzheimer's diseases). To that effect, we combine human-chimpanzee divergence patterns with polymorphism data obtained from target resequencing 20 central chimpanzees, our closest relatives with largest long-term effective population size. By using the distribution of fitness effect-alpha extension of the McDonald-Kreitman test, we reproduce inferences of rates of evolution previously based only on divergence data on both coding and intronic sequences and also obtain inferences for other classes of genomic elements (untranslated regions, promoters, and conserved noncoding sequences). Our results suggest that 1) the distribution of fitness effect-alpha method successfully helps distinguishing different scenarios of accelerated divergence (adaptation or relaxed selective constraints) and 2) the adaptive history of coding and noncoding sequences within the gene sets analyzed is decoupled.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Santpere G, Carnero-Montoro E, Petit N, Serra F, Hvilsom C, Rambla J et al. Analysis of five gene sets in chimpanzees suggests decoupling between the action of selection on protein-coding and on noncoding elements. Genome Biol Evol. 2015;7(6):1490-505. DOI: 10.1093/gbe/evv082ca
- dc.identifier.doi http://dx.doi.org/10.1093/gbe/evv082
- dc.identifier.issn 1759-6653
- dc.identifier.uri http://hdl.handle.net/10230/25071
- dc.language.iso engca
- dc.publisher Oxford University Pressca
- dc.relation.ispartof Genome biology and evolution. 2015;7(6):1490-505
- dc.rights © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.keyword Chimpanzee
- dc.subject.keyword Biochemical pathways
- dc.subject.keyword Natural selection
- dc.subject.keyword Distribution of fitness effects
- dc.subject.keyword Fraction of adaptive subsubstitution (a) and adaptive substitution rate (oa)
- dc.subject.other Alzheimerca
- dc.subject.other Parkinsonca
- dc.subject.other Ximpanzés -- Genèticaca
- dc.subject.other Parkinson, Malaltia de -- Aspectes genèticsca
- dc.subject.other Alzheimer, Malaltia d' -- Aspectes genèticsca
- dc.title Analysis of five gene sets in chimpanzees suggests decoupling between the action of selection on protein-coding and on noncoding elementsca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca