Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility

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• dc.contributor.author Sud, Amit
• dc.contributor.author Houlston, Richard S.
• dc.date.accessioned 2024-10-21T06:22:09Z
• dc.date.available 2024-10-21T06:22:09Z
• dc.date.issued 2017
• dc.description.abstract Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10−8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10−17), 6q23.3 (rs6928977, P = 4.62 × 10−11), 10p14 (rs3781093, P = 9.49 × 10−13), 13q34 (rs112998813, P = 4.58 × 10−8) and 16p13.13 (rs34972832, P = 2.12 × 10−8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.
• dc.format.mimetype application/pdf
• dc.identifier.citation Sud A, Thomsen H, Law PJ, Försti A, da Silva MI, Holroyd A, et al. Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Nat Commun. 2017 Dec 1;8(1):1892. DOI: 10.1038/s41467-017-00320-1
• dc.identifier.doi http://dx.doi.org/10.1038/s41467-017-00320-1
• dc.identifier.issn 2041-1723
• dc.identifier.uri http://hdl.handle.net/10230/68246
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nature Communications. 2017 Dec 1;8(1):1892
• dc.rights This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.other Genomes
• dc.subject.other Hodgkin, Malaltia de
• dc.subject.other Limfomes
• dc.title Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion