Predicting Response Trajectories during Cognitive-Behavioural Therapy for Panic Disorder: No Association with the BDNF Gene or Childhood Maltreatment.

Santacana, Martí; Arias, Bárbara; Mitjans, Marina; Bonillo, Albert; Montoro, María; Rosado, Silvia; Guillamat, Roser; Vallès, Vicenç; Pérez Solá, Victor; García Forero, Carlos; Fullana Rivas, Miguel Ángel

Predicting Response Trajectories during Cognitive-Behavioural Therapy for Panic Disorder: No Association with the BDNF Gene or Childhood Maltreatment.

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dc.contributor.author Santacana, Martíca
dc.contributor.author Arias, Bárbaraca
dc.contributor.author Mitjans, Marinaca
dc.contributor.author Bonillo, Albertca
dc.contributor.author Montoro, Maríaca
dc.contributor.author Rosado, Silviaca
dc.contributor.author Guillamat, Roserca
dc.contributor.author Vallès, Vicençca
dc.contributor.author Pérez Solá, Victorca
dc.contributor.author García Forero, Carlosca
dc.contributor.author Fullana Rivas, Miguel Ángelca
dc.date.accessioned 2016-11-24T08:45:14Z
dc.date.available 2016-11-24T08:45:14Z
dc.date.issued 2016
dc.description.abstract BACKGROUND: Anxiety disorders are highly prevalent and result in low quality of life and a high social and economic cost. The efficacy of cognitive-behavioural therapy (CBT) for anxiety disorders is well established, but a substantial proportion of patients do not respond to this treatment. Understanding which genetic and environmental factors are responsible for this differential response to treatment is a key step towards "personalized medicine". Based on previous research, our objective was to test whether the BDNF Val66Met polymorphism and/or childhood maltreatment are associated with response trajectories during exposure-based CBT for panic disorder (PD). METHOD: We used Growth Mixture Modeling to identify latent classes of change (response trajectories) in patients with PD (N = 97) who underwent group manualized exposure-based CBT. We conducted logistic regression to investigate the effect on these trajectories of the BDNF Val66Met polymorphism and two different types of childhood maltreatment, abuse and neglect. RESULTS: We identified two response trajectories ("high response" and "low response"), and found that they were not significantly associated with either the genetic (BDNF Val66Met polymorphism) or childhood trauma-related variables of interest, nor with an interaction between these variables. CONCLUSIONS: We found no evidence to support an effect of the BDNF gene or childhood trauma-related variables on CBT outcome in PD. Future studies in this field may benefit from looking at other genotypes or using different (e.g. whole-genome) approaches.ca
dc.description.sponsorship This work was supported by a grant from Carlos III Health Institute/Fondo Europeo de Desarrollo Regional (www.isciii.es) to MAF (PI12/00273). The authors of this report would also like to thank the support of the Spanish Ministry of Economy and Competitivity PN 2008-2011 -Carlos III Health Institute/Fondo Europeo de Dessarrollo Regional-(PI1200018; www.mineco.gob.es), Centro de Investigación Biomédica en Red - Salud Mental-(www.cibersam.es), and the Universities and Research Secretariat, Ministry of the Vice-presidency and of the Economy and Finance of the Catalan Government (2014 SGR 1636; http://universitatsirecerca.gencat.cat/).
dc.format.mimetype application/pdfca
dc.identifier.citation Santacana M, Arias B, Mitjans M, Bonillo A, Montoro M, Rosado S. et al. Predicting Response Trajectories during Cognitive-Behavioural Therapy for Panic Disorder: No Association with the BDNF Gene or Childhood Maltreatment. PLoS One. 2016 Jun 29;11(6):e0158224. doi: 10.1371/journal.pone.0158224ca
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0158224
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/27588
dc.language.iso engca
dc.publisher Public Library of Science (PLoS) ca
dc.relation.ispartof PLoS One. 2016 Jun 29;11(6):e0158224
dc.rights © 2016 Santacana et al/nThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ca
dc.subject.other Ansietatca
dc.title Predicting Response Trajectories during Cognitive-Behavioural Therapy for Panic Disorder: No Association with the BDNF Gene or Childhood Maltreatment.ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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