Adherens junction length during tissue contraction is controlled by the mechanosensitive activity of actomyosin and junctional recycling
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- dc.contributor.author Sumi, Angughali Aheto, 1986-
- dc.contributor.author Hayes, D. Peran, 1983-
- dc.contributor.author D'Angelo, Arturo
- dc.contributor.author Colombelli, Julien
- dc.contributor.author Salbreux, Guillaume
- dc.contributor.author Dierkes, Kai
- dc.contributor.author Solon, Jérôme
- dc.date.accessioned 2019-11-13T11:18:42Z
- dc.date.available 2019-11-13T11:18:42Z
- dc.date.issued 2018
- dc.description.abstract During epithelial contraction, cells generate forces to constrict their surface and, concurrently, fine-tune the length of their adherens junctions to ensure force transmission. While many studies have focused on understanding force generation, little is known on how junctional length is controlled. Here, we show that, during amnioserosa contraction in Drosophila dorsal closure, adherens junctions reduce their length in coordination with the shrinkage of apical cell area, maintaining a nearly constant junctional straightness. We reveal that junctional straightness and integrity depend on the endocytic machinery and on the mechanosensitive activity of the actomyosin cytoskeleton. On one hand, upon junctional stretch and decrease in E-cadherin density, actomyosin relocalizes from the medial area to the junctions, thus maintaining junctional integrity. On the other hand, when junctions have excess material and ruffles, junction removal is enhanced, and high junctional straightness and tension are restored. These two mechanisms control junctional length and integrity during morphogenesis.
- dc.description.sponsorship The research leading to the results has received funding from the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) to the EMBL partnership and Centro de Excelencia Severo Ochoa and to the Plan Nacional, BFU2010-16546 and BFU2015-68754.
- dc.format.mimetype application/pdf
- dc.identifier.citation Sumi A, Hayes P, D'Angelo A, Colombelli J, Salbreux G, Dierkes K et al. Adherens junction length during tissue contraction is controlled by the mechanosensitive activity of actomyosin and junctional recycling. Dev Cell. 2018;47(4):453-63. DOI: 10.1016/j.devcel.2018.10.025
- dc.identifier.doi http://dx.doi.org/10.1016/j.devcel.2018.10.025
- dc.identifier.issn 1534-5807
- dc.identifier.uri http://hdl.handle.net/10230/42836
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Developmental Cell. 2018;47(4):453-63
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2010-16546
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-68754
- dc.rights © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Drosophila dorsal closure
- dc.subject.keyword E-cadherin
- dc.subject.keyword Actomyosin cytoskeleton
- dc.subject.keyword Adherens junction
- dc.subject.keyword Biophysical modeling
- dc.subject.keyword Endocytosis
- dc.subject.keyword Epithelial contraction
- dc.subject.keyword Morphogenesis
- dc.title Adherens junction length during tissue contraction is controlled by the mechanosensitive activity of actomyosin and junctional recycling
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion