Predictors of severe COVID-19 in kidney transplant recipients in the different epidemic waves: Analysis of the Spanish Registry

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  • dc.contributor.author Villanego, Florentino
  • dc.contributor.author Mazuecos, Auxiliadora
  • dc.contributor.author Pérez Flores, Isabel M.
  • dc.contributor.author Moreso, Francesc
  • dc.contributor.author Andrés, Amado
  • dc.contributor.author Jiménez Martín, Carlos
  • dc.contributor.author Molina, María
  • dc.contributor.author Canal, Cristina
  • dc.contributor.author Sánchez Cámara, Luis A.
  • dc.contributor.author Zárraga, Sofía
  • dc.contributor.author Ruiz Fuentes, María del Carmen
  • dc.contributor.author Aladrén, María José
  • dc.contributor.author Melilli, Edoardo
  • dc.contributor.author López, Verónica
  • dc.contributor.author Sánchez-Álvarez, Emilio
  • dc.contributor.author Crespo Barrio, Marta
  • dc.contributor.author Pascual Santos, Julio
  • dc.contributor.author Spanish Society of Nephrology COVID-19 Group
  • dc.date.accessioned 2021-08-30T06:47:55Z
  • dc.date.issued 2021
  • dc.description.abstract SARS-CoV-2 infection has produced high mortality in kidney transplant (KT) recipients, especially in the elderly. Until December 2020, 1011 KT with COVID-19 have been prospectively included in the Spanish Registry and followed until recovery or death. In multivariable analysis, age, pneumonia, and KT performed ≤6 months before COVID-19 were predictors of death, whereas gastrointestinal symptoms were protective. Survival analysis showed significant increasing mortality risk in four subgroups according to recipient age and time after KT (age <65 years and posttransplant time >6 months, age <65 and time ≤6, age ≥65 and time >6 and age ≥65 and time ≤6): mortality rates were, respectively, 11.3%, 24.5%, 35.4%, and 54.5% (p < .001). Patients were significantly younger, presented less pneumonia, and received less frequently specific anti-COVID-19 treatment in the second wave (July-December) than in the first one (March-June). Overall mortality was lower in the second wave (15.1 vs. 27.4%, p < .001) but similar in critical patients (66.7% vs. 58.1%, p = .29). The interaction between age and time post-KT should be considered when selecting recipients for transplantation in the COVID-19 pandemic. Advanced age and a recent KT should foster strict protective measures, including vaccination.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Villanego F, Mazuecos A, Pérez-Flores IM, Moreso F, Andrés A, Jiménez-Martín C, Molina M, Canal C, Sánchez-Cámara LA, Zárraga S, Ruiz-Fuentes MDC, Aladrén MJ, Melilli E, López V, Sánchez-Álvarez E, Crespo M, Pascual J; Spanish Society of Nephrology COVID-19 Group. Predictors of severe COVID-19 in kidney transplant recipients in the different epidemic waves: Analysis of the Spanish Registry. Am J Transplant. 2021;21(7):2573-82. DOI: 10.1111/ajt.16579
  • dc.identifier.doi http://dx.doi.org/10.1111/ajt.16579
  • dc.identifier.issn 1600-6135
  • dc.identifier.uri http://hdl.handle.net/10230/48342
  • dc.language.iso eng
  • dc.publisher Wiley
  • dc.relation.ispartof Am J Transplant. 2021;21(7):2573-82
  • dc.rights This is the peer reviewed version of the following article: Villanego F, Mazuecos A, Pérez-Flores IM, Moreso F, Andrés A, Jiménez-Martín C, Molina M, Canal C, Sánchez-Cámara LA, Zárraga S, Ruiz-Fuentes MDC, Aladrén MJ, Melilli E, López V, Sánchez-Álvarez E, Crespo M, Pascual J; Spanish Society of Nephrology COVID-19 Group. Predictors of severe COVID-19 in kidney transplant recipients in the different epidemic waves: Analysis of the Spanish Registry. Am J Transplant. 2021;21(7):2573-82. DOI: 10.1111/ajt.16579, which has been published in final form at http://dx.doi.org/10.1111/ajt.16579. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword Clinical research/practice
  • dc.subject.keyword Infection and infectious agents - viral
  • dc.subject.keyword Kidney transplantation/nephrology
  • dc.title Predictors of severe COVID-19 in kidney transplant recipients in the different epidemic waves: Analysis of the Spanish Registry
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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