Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine

Rosenquist, Aske Hess; Hoyer, Birgit Bjerre; Júlvez Calvo, Jordi; Sunyer Deu, Jordi; Pedersen, Henning Sloth; Lenters, Virissa; Jönsson, Bo A.G.; Bonde, Jens Peter; Toft, Gunnar

Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine

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dc.contributor.author Rosenquist, Aske Hessca
dc.contributor.author Hoyer, Birgit Bjerreca
dc.contributor.author Júlvez Calvo, Jordica
dc.contributor.author Sunyer Deu, Jordica
dc.contributor.author Pedersen, Henning Slothca
dc.contributor.author Lenters, Virissaca
dc.contributor.author Jönsson, Bo A.G.ca
dc.contributor.author Bonde, Jens Peterca
dc.contributor.author Toft, Gunnarca
dc.date.accessioned 2018-03-01T14:49:53Z
dc.date.available 2018-03-01T14:49:53Z
dc.date.issued 2017
dc.description.abstract BACKGROUND: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior. OBJECTIVE: We investigated the association between prenatal and early-life exposures to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) and behaviors in children between 5 and 9 y of age. METHODS: In the Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) cohort, consisting of mother-child pairs from Greenland and Ukraine (n=1,018), maternal serum PCB-153 and p,p'-DDE concentrations were measured during pregnancy, and cumulative postnatal exposures during the first 12 months after delivery were estimated using a pharmacokinetic model. Parents completed the Strengths and Difficulties Questionnaire (SDQ), and children's behaviors were dichotomized as abnormal (high) versus normal/borderline for five SDQ subscales and the total difficulties score. RESULTS: The total difficulties score, an overall measure of abnormal behavior, was not clearly associated with pre- or postnatal exposures to PCB-153 or to p,p'-DDE. However, pooled adjusted odds ratios (ORs) for high conduct problem scores with a doubling of exposure were 1.19 (95% CI: 0.99, 1.42) and 1.16 (95% CI: 0.96, 1.41) for pre- and postnatal PCB-153, respectively, and 1.25 (95% CI: 1.04, 1.51) and 1.24 (95% CI: 1.01, 1.51) for pre- and postnatal p,p'-DDE, respectively. Corresponding ORs for high hyperactivity scores were 1.24 (95% CI: 0.94, 1.62) and 1.08 (95% CI: 0.81, 1.45) for pre- and postnatal PCB-153, respectively, and 1.43 (95% CI: 1.06, 1.92) and 1.27 (95% CI: 0.93, 1.73) for pre- and postnatal p,p'-DDE, respectively. CONCLUSION: Prenatal and early postnatal exposures to p,p'-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5-9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age. https://doi.org/10.1289/EHP553.
dc.description.sponsorship The Climate change, environmental contaminants and reproductive health (CLEAR) and Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) studies were funded by the European Commission's 7th and 5th Framework Programmes, respectively (grant nos. FP7-ENV-2008-1-226217 and QLK4-CT-2001-00202, respectively). A.H.R. received grants from The Danish Council for Independent Research - Medical Sciences (5053-00064A), the A.P. Møller Foundation (15-338), the Oticon Foundation (15-3689), and the Spar Nord Foundation.
dc.format.mimetype application/pdf
dc.identifier.citation Rosenquist AH, Høyer BB, Julvez J, Sunyer J, Pedersen HS, Lenters V et al. Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine. Environ Health Perspect. 2017 Oct 3;125(10):107002. DOI: 10.1289/EHP553
dc.identifier.doi http://dx.doi.org/10.1289/EHP553
dc.identifier.issn 0091-6765
dc.identifier.uri http://hdl.handle.net/10230/34030
dc.language.iso eng
dc.publisher National Institute of Environmental Health Sciencesca
dc.relation.ispartof Environ Health Perspect. 2017 Oct 3;125(10):107002
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226217
dc.rights Reproduced from Environmental Health Perspectives http://dx.doi.org/10.1289/EHP553
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.keyword Dichlorodiphenyl dichloroethylene/blood
dc.subject.keyword Polychlorinated biphenyls/blood
dc.subject.keyword Child development
dc.subject.keyword Child behavior
dc.subject.keyword Environmental exposure
dc.subject.keyword Environmental pollutants/blood
dc.title Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraineca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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