Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abdita
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- dc.contributor.author Karl R., Wottonca
- dc.contributor.author Jiménez Guri, Evaca
- dc.contributor.author Crombach, Antonca
- dc.contributor.author Janssens, Hildeca
- dc.contributor.author Alcaine Colet, Anna, 1992-ca
- dc.contributor.author Lemke, Steffenca
- dc.contributor.author Schmidt Ott, Ursca
- dc.contributor.author Jaeger, Johannes, 1973-ca
- dc.date.accessioned 2015-11-10T13:54:16Z
- dc.date.available 2015-11-10T13:54:16Z
- dc.date.issued 2015
- dc.description.abstract The segmentation gene network in insects can produce equivalent phenotypic outputs despite differences in upstream regulatory inputs between species. We investigate the mechanistic basis of this phenomenon through a systems-level analysis of the gap gene network in the scuttle fly Megaselia abdita (Phoridae). It combines quantification of gene expression at high spatio-temporal resolution with systematic knock-downs by RNA interference (RNAi). Initiation and dynamics of gap gene expression differ markedly between M. abdita and Drosophila melanogaster, while the output of the system converges to equivalent patterns at the end of the blastoderm stage. Although the qualitative structure of the gap gene network is conserved, there are differences in the strength of regulatory interactions between species. We term such network rewiring ‘quantitative system drift’. It provides a mechanistic explanation for the developmental hourglass model in the dipteran lineage. Quantitative system drift is likely to be a widespread mechanism for developmental evolution.en
- dc.description.sponsorship This work was supported by the EU project “BioPreDyn” (EC FP7-KBBE-2011-5, grant number 289434)en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Wotton KR, Jiménez-Guri E, Crombach A, Janssens H, Alcaine-Colet A, Lemke S et al. Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abdita. Elife. 2015;4:e04785. DOI: 10.7554/eLife.04785.001ca
- dc.identifier.doi http://dx.doi.org/10.7554/eLife.04785.001
- dc.identifier.issn 2050-084X
- dc.identifier.uri http://hdl.handle.net/10230/25033
- dc.language.iso engca
- dc.publisher eLifeca
- dc.relation.ispartof Elife. 2015;4:e04785
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/289434
- dc.rights Copyright Wotton et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.en
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.other Drosòfilaca
- dc.subject.other Genètica molecularca
- dc.subject.other RNA missatgerca
- dc.title Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abditaen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca