Understanding the neurological implications of acute and long COVID using brain organoids

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  • dc.contributor.author García González, Laura
  • dc.contributor.author Martí Sarrias, Andrea
  • dc.contributor.author Puertas, Maria C.
  • dc.contributor.author Bayón-Gil, Ángel
  • dc.contributor.author Resa Infante, Patricia
  • dc.contributor.author Martinez Picado, Javier
  • dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-
  • dc.contributor.author Acosta, Sandra
  • dc.date.accessioned 2023-10-30T07:07:51Z
  • dc.date.available 2023-10-30T07:07:51Z
  • dc.date.issued 2023
  • dc.description.abstract As early as in the acute phase of the coronavirus disease 2019 (COVID-19) pandemic, the research community voiced concerns about the long-term implications of infection. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like many other viruses, can trigger chronic disorders that last months or even years. Long COVID, the chronic and persistent disorder lasting more than 12 weeks after the primary infection with SARS-CoV-2, involves a variable number of neurological manifestations, ranging from mild to severe and even fatal. In vitro and in vivo modeling suggest that SARS-CoV-2 infection drives changes within neurons, glia and the brain vasculature. In this Review, we summarize the current understanding of the neuropathology of acute and long COVID, with particular emphasis on the knowledge derived from brain organoid models. We highlight the advantages and main limitations of brain organoids, leveraging their human-derived origin, their similarity in cellular and tissue architecture to human tissues, and their potential to decipher the pathophysiology of long COVID.
  • dc.description.sponsorship This work is funded by Fundació la Marató de TV3 (2021-30/31/32) to S.A., J.M.-P. and A.N., and project 3D4COVID by Merck Sharp and Dohme Investigator Studies Program (code MISP# IIS 60258) to J.M.-P. and S.A. J.M.-P. is supported by grant PID2019-109870RB-I00 from Ministerio de Ciencia e Innovación. L.G.-G. is supported by a Margarita Salas Fellowship (2021UPF-MS-28) from Ministerio de Ciencia e Innovación, funded by the European Union-NextGenerationEU, Ministry of Universities and Recovery, Transformation and Resilience Plan, through Universitat Pompeu Fabra.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation García-González L, Martí-Sarrias A, Puertas MC, Bayón-Gil Á, Resa-Infante P, Martinez-Picado J, Navarro A, Acosta S. Understanding the neurological implications of acute and long COVID using brain organoids. Dis Model Mech. 2023 Jul 1;16(7):dmm050049. DOI: 10.1242/dmm.050049
  • dc.identifier.doi http://dx.doi.org/10.1242/dmm.050049
  • dc.identifier.issn 1754-8403
  • dc.identifier.uri http://hdl.handle.net/10230/58177
  • dc.language.iso eng
  • dc.publisher Company of Biologists
  • dc.relation.ispartof Dis Model Mech. 2023 Jul 1;16(7):dmm050049
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-109870RB-I00
  • dc.rights © 2023. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0
  • dc.subject.keyword Brain organoids
  • dc.subject.keyword Long COVID
  • dc.subject.keyword Neurological affectations
  • dc.subject.keyword SARS-CoV-2
  • dc.title Understanding the neurological implications of acute and long COVID using brain organoids
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion