Emergent chemical behavior in variable-volume protocells
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- dc.contributor.author Shirt-Ediss, Benca
- dc.contributor.author Solé Vicente, Ricard, 1962-ca
- dc.contributor.author Ruíz-Mirazo, Kepaca
- dc.date.accessioned 2016-01-27T14:41:50Z
- dc.date.available 2016-01-27T14:41:50Z
- dc.date.issued 2015
- dc.description.abstract Artificial protocellular compartments and lipid vesicles have been used as model systems to understand the origins and requirements for early cells, as well as to design encapsulated reactors for biotechnology. One prominent feature of vesicles is the semi-permeable nature of their membranes, able to support passive diffusion of individual solute species into/out of the compartment, in addition to an osmotic water flow in the opposite direction to the net solute concentration gradient. Crucially, this water flow affects the internal aqueous volume of the vesicle in response to osmotic imbalances, in particular those created by ongoing reactions within the system. In this theoretical study, we pay attention to this often overlooked aspect and show, via the use of a simple semi-spatial vesicle reactor model, that a changing solvent volume introduces interesting non-linearities into an encapsulated chemistry. Focusing on bistability, we demonstrate how a changing volume compartment can degenerate existing bistable reactions, but also promote emergent bistability from very simple reactions, which are not bistable in bulk conditions. One particularly remarkable effect is that two or more chemically-independent reactions, with mutually exclusive reaction kinetics, are able to couple their dynamics through the variation of solvent volume inside the vesicle. Our results suggest that other chemical innovations should be expected when more realistic and active properties of protocellular compartments are taken into account.ca
- dc.description.sponsorship This work was supported by the Botin Foundation and by the Santa Fe Institute, and Kepa Ruiz-Mirazo acknowledges financial support from the Basque Government (IT 590-13), Spanish Ministry of Economía y Competitividad (FFI2011-25665) and European COST Actions CM1304 and TD1308.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Shirt-Ediss B, Solé RV, Ruiz-Mirazo K. Emergent chemical behavior in variable-volume protocells. Life. 2015;5(1):181-211. DOI: 10.3390/life5010181ca
- dc.identifier.doi http://dx.doi.org/10.3390/life5010181
- dc.identifier.issn 2075-1729
- dc.identifier.uri http://hdl.handle.net/10230/25667
- dc.language.iso engca
- dc.publisher MPDIca
- dc.relation.ispartof Life. 2015;5(1):181-211
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/FFI2011-25665
- dc.rights © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.keyword Semi-permeable compartments
- dc.subject.keyword Osmosis
- dc.subject.keyword Variable solvent volume
- dc.subject.keyword Mass action
- dc.subject.keyword Kinetics (MAK)
- dc.subject.keyword Chemical reactor
- dc.subject.keyword Continuous-flow stirred tank reactor (CSTR)
- dc.subject.keyword Bistability
- dc.subject.keyword Systems chemistry
- dc.subject.keyword Osmotic coupling
- dc.subject.other Osmosica
- dc.title Emergent chemical behavior in variable-volume protocellsca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca