Mechanisms of cell specification and differentiation in vertebrate cranial sensory systems
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Alsina i Español, Berta
- dc.date.accessioned 2022-02-01T07:32:41Z
- dc.date.available 2022-02-01T07:32:41Z
- dc.date.issued 2020
- dc.description.abstract Vertebrates sense a large variety of sensory stimuli that ranges from temperature, volatile and nonvolatile chemicals, touch, pain, light, sound and gravity. To achieve this, they use specialized cells present in sensory organs and cranial ganglia. Much of our understanding of the transcription factors and mechanisms responsible for sensory cell specification comes from cell-lineage tracing and genetic experiments in different species, but recent advances in single-cell transcriptomics, high-resolution imaging and systems biology approaches have allowed to study these processes in an unprecedented resolution. Here I will point to the transcription factor programs driving cell diversity in the different sensory organs of vertebrates to then discuss in vivo data of how cell specification is coupled with tissue morphogenesis.
- dc.description.sponsorship This work was by supported by grant BFU2017-82723P from MCINN to BA and the Unidad de Excelencia Maria de Maeztu (MDM-2014-0370).
- dc.format.mimetype application/pdf
- dc.identifier.citation Alsina B. Mechanisms of cell specification and differentiation in vertebrate cranial sensory systems. Curr Opin Cell Biol. 2020;67:79-85. DOI: 10.1016/j.ceb.2020.08.006
- dc.identifier.doi http://dx.doi.org/10.1016/j.ceb.2020.08.006
- dc.identifier.issn 0955-0674
- dc.identifier.uri http://hdl.handle.net/10230/52377
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Curr Opin Cell Biol. 2020;67:79-85
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-82723P
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.ceb.2020.08.006
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Cell identity
- dc.subject.keyword Cell specification
- dc.subject.keyword Cranial placodes
- dc.subject.keyword Hair cells
- dc.subject.keyword Morphogenesis
- dc.subject.keyword Olfactory
- dc.subject.keyword Sensory neurons
- dc.subject.keyword Sensory systems
- dc.subject.keyword Transcription factors
- dc.subject.keyword scRNA-seq
- dc.title Mechanisms of cell specification and differentiation in vertebrate cranial sensory systems
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion