Prenatal exposure to residential air pollution and infant mental development: modulation by antioxidants and detoxification factors

Guxens Junyent, Mònica; Aguilera Jiménez, Inmaculada, 1977-; Ballester Díez, Ferran; Estarlich, Marisa; Fernández Somoano, Ana; Lertxundi, Aitana; Lertxundi, Nerea; Mendez, Michelle A.; Tardón, Adonina; Vrijheid, Martine; Sunyer Deu, Jordi; INMA (Infancia y Medio Ambiente) Project

Prenatal exposure to residential air pollution and infant mental development: modulation by antioxidants and detoxification factors

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dc.contributor.author Guxens Junyent, Mònicaca
dc.contributor.author Aguilera Jiménez, Inmaculada, 1977-ca
dc.contributor.author Ballester Díez, Ferranca
dc.contributor.author Estarlich, Marisaca
dc.contributor.author Fernández Somoano, Anaca
dc.contributor.author Lertxundi, Aitanaca
dc.contributor.author Lertxundi, Nereaca
dc.contributor.author Mendez, Michelle A.ca
dc.contributor.author Tardón, Adoninaca
dc.contributor.author Vrijheid, Martineca
dc.contributor.author Sunyer Deu, Jordica
dc.contributor.author INMA (Infancia y Medio Ambiente) Projectca
dc.date.accessioned 2015-04-08T10:15:04Z
dc.date.available 2015-04-08T10:15:04Z
dc.date.issued 2012ca
dc.description.abstract Background: Air pollution effects on children’s neurodevelopment have recently been suggested to occur most likely through the oxidative stress pathway. Objective: We aimed to assess whether prenatal exposure to residential air pollution is associated with impaired infant mental development, and whether antioxidant/detoxification factors modulate this association. Methods: In the Spanish INfancia y Medio Ambiente (INMA; Environment and Childhood) Project, 2,644 pregnant women were recruited during their first trimester. Nitrogen dioxide (NO2) and benzene were measured with passive samplers covering the study areas. Land use regression models were developed for each pollutant to predict average outdoor air pollution levels for the entire pregnancy at each residential address. Maternal diet was obtained at first trimester through a validated food frequency questionnaire. Around 14 months, infant mental development was assessed using Bayley Scales of Infant Development. Results: Among the 1,889 children included in the analysis, mean exposure during pregnancy was 29.0 μg/m3 for NO2 and 1.5 μg/m3 for benzene. Exposure to NO2 and benzene showed an inverse association with mental development, although not statistically significant, after adjusting for potential confounders [β (95% confidence interval) = –0.95 (–3.90, 1.89) and –1.57 (–3.69, 0.56), respectively, for a doubling of each compound]. Stronger inverse associations were estimated for both pollutants among infants whose mothers reported low intakes of fruits/vegetables during pregnancy [–4.13 (–7.06, –1.21) and –4.37 (–6.89, –1.86) for NO2 and benzene, respectively], with little evidence of associations in the high-intake group (interaction p-values of 0.073 and 0.047). Inverse associations were also stronger in non-breast-fed infants and infants with low maternal vitamin D, but effect estimates and interactions were not significant. Conclusions: Our findings suggest that prenatal exposure to residential air pollutants may adversely affect infant mental development, but potential effects may be limited to infants whose mothers report low antioxidant intakes.en
dc.description.sponsorship This study was funded by grants from the Spanish Ministry of Health-Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, FIS-PI041436, FIS- PI081151, FIS-PI042018, FIS-PI09/02311, FIS-PI06/0867, FIS-PS09/00090, FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, and 09/02647), Generalitat de Catalunya-CIRIT (Consell Interdepartamental de Recerca i Innovació Tecnològica) (1999SGR 00241), Conselleria de Sanitat Generalitat Valenciana, Universidad de Oviedo, Obra social Cajastur, Department of Health of the Basque Government (2005111093 and 2009111069), the Provincial Government of Gipuzkoa (DFG06/004 and DFG08/001), and Fundación Roger Tornéen
dc.format.mimetype application/pdfca
dc.identifier.citation Guxens M, Aguilera I, Ballester F, Estarlich M, Fernandez-Somoano A, Lertxundi A et al. Prenatal exposure to residential air pollution and infant mental development: modulation by antioxidants and detoxification factors. Environ Health Perspect. 2012;120(1):144-9. DOI: 10.1289/ehp.1103469ca
dc.identifier.doi http://dx.doi.org/10.1289/ehp.1103469
dc.identifier.issn 0091-6765ca
dc.identifier.uri http://hdl.handle.net/10230/23359
dc.language.iso engca
dc.publisher National Institute of Environmental Health Sciences (NIEHS)ca
dc.relation.ispartof Environmental Health Perspectives. 2012;120(1):144-9
dc.rights Reproduced with permission from Environmental Health Perspectivesca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.keyword Aromatic hydrocarbonsen
dc.subject.keyword Breast-feedingen
dc.subject.keyword Child developmenten
dc.subject.keyword Cognitionen
dc.subject.keyword Environmental pollutionen
dc.subject.keyword Fruiten
dc.subject.keyword Intelligenceen
dc.subject.keyword Nitrogen dioxideen
dc.subject.keyword Vegetablesen
dc.subject.keyword Vitamin Den
dc.subject.other Infants -- Creixementca
dc.subject.other Vitamines en nutrició humanaca
dc.subject.other Infants -- Alimentacióca
dc.subject.other Nodrissons -- Alimentacióca
dc.title Prenatal exposure to residential air pollution and infant mental development: modulation by antioxidants and detoxification factorsen
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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