Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals

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• dc.contributor.author Collij, Lyduine E.
• dc.contributor.author Mastenbroek, Sophie E.
• dc.contributor.author Salvadó, Gemma
• dc.contributor.author Wink, Alle Meije
• dc.contributor.author Visser, Pieter Jelle
• dc.contributor.author Barkhof, Frederik
• dc.contributor.author van Berckel, Bart N. M.
• dc.contributor.author Lopes Alves, Isadora
• dc.date.accessioned 2022-05-05T07:41:07Z
• dc.date.available 2022-05-05T07:41:07Z
• dc.date.issued 2021
• dc.description.abstract Introduction: The value of quantitative longitudinal and regional amyloid beta (Aβ) measurements in predicting cognitive decline in initially cognitively unimpaired (CU) individuals remains to be determined. Methods: We selected 133 CU individuals with two or more [11C]Pittsburgh compound B ([11C]PiB) scans and neuropsychological data from Open Access Series of Imaging Studies (OASIS-3). Baseline and annualized distribution volume ratios were computed for a global composite and four regional clusters. The predictive value of Aβ measurements (baseline, slope, and interaction) on longitudinal cognitive performance was examined. Results: Global performance could only be predicted by Aβ burden in an early cluster (precuneus, lateral orbitofrontal, and insula) and the precuneus region of interest (ROI) by itself significantly improved the model. Precuneal Aβ burden was also predictive of immediate and delayed episodic memory performance. In Aβ subjects at baseline (N = 93), lateral orbitofrontal Aβ burden predicted working and semantic memory performance. Discussion: Quantifying longitudinal and regional changes in Aβ can improve the prediction of cognitive functioning in initially CU individuals.
• dc.description.sponsorship This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No. 115952. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation program and EFPIA. This communication reflects the views of the authors and neither IMI nor the European Union and EFPIA are liable for any use that may be made of the information contained herein. FB is supported by the NIHR UCLH biomedical research center. FB and AMW are supported by the European Union's Horizon 2020 research and innovation program under grant agreement No. 666992. Data were provided by OASIS‐3. Principal Investigators: T. Benzinger, D. Marcus, J. Morris; NIH P50AG00561, P30NS09857781, P01AG026276, P01AG003991, R01AG043434, UL1TR000448, and R01EB009352.
• dc.format.mimetype application/pdf
• dc.identifier.citation Collij LE, Mastenbroek SE, Salvadó G, Wink AM, Visser PJ, Barkhof F, et al. Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals. Alzheimers Dement (Amst). 2021 Aug 2; 13(1): e12216. DOI: 10.1002/dad2.12216
• dc.identifier.doi http://dx.doi.org/10.1002/dad2.12216
• dc.identifier.issn 2352-8729
• dc.identifier.uri http://hdl.handle.net/10230/52992
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/115952
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/666992
• dc.rights This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Alzheimer's disease
• dc.subject.keyword Amyloid beta
• dc.subject.keyword Longitudinal
• dc.subject.keyword Positron emission tomography
• dc.subject.keyword Regional
• dc.title Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion