Omega-3 blood biomarkers relate to brain glucose uptake in individuals at risk of Alzheimer's disease dementia

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Lázaro, Iolanda
  • dc.contributor.author Grau-Rivera, Oriol
  • dc.contributor.author Suárez-Calvet, Marc
  • dc.contributor.author Fauria, Karine
  • dc.contributor.author Minguillón, Carolina
  • dc.contributor.author Shekari, Mahnaz
  • dc.contributor.author Falcón, Carles
  • dc.contributor.author Garcia Prat, Marina
  • dc.contributor.author Huguet, Jordi
  • dc.contributor.author Molinuevo, José Luis
  • dc.contributor.author Gispert López, Juan Domingo
  • dc.contributor.author Sala Vila, Aleix
  • dc.contributor.author ALFA Study
  • dc.date.accessioned 2025-02-18T06:16:40Z
  • dc.date.available 2025-02-18T06:16:40Z
  • dc.date.issued 2024
  • dc.description.abstract Introduction: Brain glucose hypometabolism is a preclinical feature of Alzheimer's disease (AD). Dietary omega-3 fatty acids promote brain glucose metabolism, but clinical research is incipient. Circulating omega-3s objectively reflect their dietary intake. Methods: This was a cross-sectional study in 320 cognitively unimpaired participants at increased risk of AD dementia. Using lipidomics, we determined blood docosahexaenoic (DHA) and alpha-linolenic (ALA) acid levels (omega-3s from marine and plant origin, respectively). We assessed brain glucose metabolism using [18-F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). Results: Blood ALA directly related to FDG uptake in brain areas known to be affected in AD. Stronger associations were observed in apolipoprotein E ε4 carriers and homozygotes. For DHA, significant direct associations were restricted to amyloid beta-positive tau-positive participants. Discussion: Blood omega-3 directly relate to preserved glucose metabolism in AD-vulnerable brain regions in individuals at increased risk of AD dementia. This adds to the benefits of omega-3 supplementation in the preclinical stage of AD dementia. Highlights: Blood omega-3s were related to brain glucose uptake in participants at risk of Alzheimer's disease (AD) dementia.Complementary associations were observed for omega-3 from marine and plant sources.Foods rich in omega-3 might be useful in early features of AD.
  • dc.description.sponsorship The research leading to these results has received funding from “la Caixa” Foundation (ID 100010434), under agreement LCF/PR/GN17/50300004 and the Alzheimer's Association and an international anonymous charity foundation through the TriBEKa Imaging Platform project (TriBEKa-17-519007). Additional support has been received from the Universities and Research Secretariat, Ministry of Business and Knowledge of the Catalan Government under the grant no. 2021 SGR 00913. OG-R is supported by the Spanish Ministry of Science and Innovation –State Research Agency (IJC2020-043417-I/MCIN/AEI/10.13039/501100011033) and the European Union laquoNextGenerationEUraquo/PRTR. MSC receives funding from the European Research Council (ERC) under the European Unionʼs Horizon 2020 research and innovation programme (Grant agreement No. 948677), Project “PI19/00155,” funded by Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union, and from a fellowship from “la Caixa” Foundation (ID 100010434) and from the European Unionʼs Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 847648(LCF/BQ/PR21/11840004). This work was supported by funding from Instituto de Salud Carlos III (PI22/00071) and by a grant from the California Walnut Commission, Folsom, CA, US (to AS-V). The funding agencies had no input in the study design, data collection, analyses, or writing and submission of the manuscript.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Lázaro I, Grau-Rivera O, Suárez-Calvet M, Fauria K, Minguillón C, Shekari M, et al. Omega-3 blood biomarkers relate to brain glucose uptake in individuals at risk of Alzheimer's disease dementia. Alzheimers Dement (Amst). 2024 Jul 5;16(3):e12596. DOI: 10.1002/dad2.12596
  • dc.identifier.doi http://dx.doi.org/10.1002/dad2.12596
  • dc.identifier.issn 2352-8729
  • dc.identifier.uri http://hdl.handle.net/10230/69622
  • dc.language.iso eng
  • dc.publisher Wiley
  • dc.relation.ispartof Alzheimers Dement (Amst). 2024 Jul 5;16(3):e12596
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/948677
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/847648
  • dc.rights © 2024 The Author(s). Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Biomarkers
  • dc.subject.keyword Diet
  • dc.subject.keyword Fatty fish
  • dc.subject.keyword Fish oil
  • dc.subject.keyword Nuts
  • dc.subject.keyword n‐3 fatty acids
  • dc.subject.keyword Polyunsaturated fatty acids
  • dc.subject.keyword Walnuts
  • dc.title Omega-3 blood biomarkers relate to brain glucose uptake in individuals at risk of Alzheimer's disease dementia
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Hospital del Mar Research Institute)
Articles (Departament de Medicina i Ciències de la Vida)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)