Relationship between thyroid-stimulating hormone, BDNF levels, and hippocampal volume in antipsychotic-naïve first-episode psychosis patients

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• dc.contributor.author Toll Privat, Alba
• dc.contributor.author Blanco Hinojo, Laura, 1981-
• dc.contributor.author Berge Baquero, Daniel
• dc.contributor.author Manzano, Ana
• dc.contributor.author El Abidi, Kadhija
• dc.contributor.author Pérez Solá, Victor
• dc.contributor.author Mané Santacana, Anna
• dc.date.accessioned 2024-03-19T07:32:37Z
• dc.date.available 2024-03-19T07:32:37Z
• dc.date.issued 2023
• dc.description.abstract Introduction: Thyroid hormones play an essential role in hippocampal development, a key structure in psychosis. However, the role of these hormones in first-episode psychosis (FEP) has received limited attention. It has been hypothesized that thyroid hormones could cause morphological modifications in the hippocampal structure through the upregulation of brain-derived neurotrophic factor (BDNF). In this study, we primarily aimed to determine the relationship between thyroid-stimulating hormone (TSH) levels, peripheral BDNF levels, and hippocampal volume in antipsychotic-naïve FEP patients. We also aimed to determine whether TSH levels were associated with clinical symptomatology. Materials and methods: A total of 50 antipsychotic-naïve FEP patients were included in the study. At baseline, we collected fasting blood samples and registered sociodemographic and clinical variables (substance use, DUP, PANSS, GAF, and CDSS). Structural T1 MRI was performed at baseline to quantify brain volumes. No control group was used for this study. Results: Of the 50 patients, more than one-third (36%) presented alterations in TSH levels, mainly elevated levels (32% of patients). The TSH levels were inversely correlated with both peripheral BDNF and hippocampal volume. On the multivariate analysis, the model that best predicted the relative hippocampal volume was a single variable model (TSH levels). No significant association was observed between TSH levels and clinical symptomatology. Discussion: These results suggest that thyroid hormones could have a neuroprotective effect on the hippocampus in FEP patients, possibly through their effect by increasing BDNF concentrations, which could attenuate brain injury and neuroinflammation. Nevertheless, thyroid hormones could also affect hippocampal volume through other pathways.
• dc.format.mimetype application/pdf
• dc.identifier.citation Toll A, Blanco-Hinojo L, Berge D, Manzano A, El Abidi K, Perez-Solà V, et al. Relationship between thyroid-stimulating hormone, BDNF levels, and hippocampal volume in antipsychotic-naïve first-episode psychosis patients. Front Psychiatry. 2023 Dec 7;14:1301714. DOI: 10.3389/fpsyt.2023.1301714
• dc.identifier.doi http://dx.doi.org/10.3389/fpsyt.2023.1301714
• dc.identifier.issn 1664-0640
• dc.identifier.uri http://hdl.handle.net/10230/59479
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Front Psychiatry. 2023 Dec 7;14:1301714
• dc.rights © 2023 Toll, Blanco-Hinojo, Berge, Manzano, El Abidi, Perez-Solà and Mané. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword BDNF (brain derived neurotrophic factor)
• dc.subject.keyword TSH (thyroid stimulating hormone)
• dc.subject.keyword Drug-naïve
• dc.subject.keyword First episode psychosis (FEP)
• dc.subject.keyword Hippocampal volume
• dc.subject.keyword Hippocampus
• dc.subject.keyword Thyroid hormone
• dc.title Relationship between thyroid-stimulating hormone, BDNF levels, and hippocampal volume in antipsychotic-naïve first-episode psychosis patients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion