Effect of heat treatment on osteoblast performance and bactericidal behavior of Ti6Al4V(ELI)-3at.%Cu fabricated by laser powder bed fusion

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• dc.contributor.author Martín Vilardell, Anna
• dc.contributor.author Cantillo Alzamora, Vanesa
• dc.contributor.author Bauso, Luana Vittoria
• dc.contributor.author Madrid, Cristina
• dc.contributor.author Krakhmalev, Pavel
• dc.contributor.author Albu, Mihaela
• dc.contributor.author Yadroitsava, Ina
• dc.contributor.author Yadroitsev, Igor
• dc.contributor.author Garcia Giralt, Natàlia
• dc.date.accessioned 2024-04-29T07:21:24Z
• dc.date.available 2024-04-29T07:21:24Z
• dc.date.issued 2023
• dc.description.abstract Cu addition to alloys for biomedical applications has been of great interest to reduce bacterial growth. In situ-alloyed Ti6Al4V(ELI)-3at.%Cu was successfully manufactured by laser powder bed fusion (L-PBF). Even so, post-heat treatments are required to avoid distortions and/or achieve required/desired mechanical and fatigue properties. The present study is focused on the investigation of microstructural changes in L-PBF Ti6Al4V(ELI)-3at.%Cu after stress relieving and annealing treatments, as well as their influence on osteoblast and bactericidal behavior. After the stress relieving treatment, a homogenously distributed β phase and CuTi2 intermetallic precipitates were observed over the αʹ matrix. The annealing treatment led to the increase in amount and size of both types of precipitates, but also to phase redistribution along α lamellas. Although microstructural changes were not statistically significant, such increase in β and CuTi2 content resulted in an increase in osteoblast proliferation after 14 days of cell culture. A significant bactericidal behavior of L-PBF Ti6Al4V(ELI)-3at.%Cu by means of ion release was found after the annealing treatment, provably due to the easier release of Cu ions from β phase. Biofilm formation was inhibited in all on Cu-alloyed specimens with stress relieving but also annealing treatment.
• dc.format.mimetype application/pdf
• dc.identifier.citation Martín Vilardell A, Cantillo Alzamora V, Bauso LV, Madrid C, Krakhmalev P, Albu M, et al. Effect of heat treatment on osteoblast performance and bactericidal behavior of Ti6Al4V(ELI)-3at.%Cu fabricated by laser powder bed fusion. J Funct Biomater. 2023 Jan 23;14(2):63. DOI: 10.3390/jfb14020063
• dc.identifier.doi http://dx.doi.org/10.3390/jfb14020063
• dc.identifier.issn 2079-4983
• dc.identifier.uri http://hdl.handle.net/10230/59929
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof J Funct Biomater. 2023 Jan 23;14(2):63
• dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Laser powder bed fusion
• dc.subject.keyword Ti–Cu alloys
• dc.subject.keyword Heat treatment
• dc.subject.keyword Microstructure
• dc.subject.keyword Osteoblast activity
• dc.subject.keyword Bactericidal effect
• dc.title Effect of heat treatment on osteoblast performance and bactericidal behavior of Ti6Al4V(ELI)-3at.%Cu fabricated by laser powder bed fusion
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion