Mapping the self in the brain's default mode network
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Davey, Christopher G.ca
- dc.contributor.author Pujol, Jesúsca
- dc.contributor.author Harrison, Ben J.ca
- dc.date.accessioned 2016-05-02T11:02:29Z
- dc.date.issued 2016
- dc.description.abstract The brain's default mode network (DMN) has become closely associated with self-referential mental activity, particularly in the resting-state. While the DMN is important for such processes, it has functions other than self-reference, and self-referential processes are supported by regions outside of the DMN. In our study of 88 participants, we examined self-referential and resting-state processes to clarify the extent to which DMN activity was common and distinct between the conditions. Within areas commonly activated by self-reference and rest we sought to identify those that showed additional functional specialization for self-referential processes: these being not only activated by self-reference and rest but also showing increased activity in self-reference versus rest. We examined the neural network properties of the identified 'core-self' DMN regions-in medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and inferior parietal lobule-using dynamic causal modeling. The optimal model identified was one in which self-related processes were driven via PCC activity and moderated by the regulatory influences of MPFC. We thus confirm the significance of these regions for self-related processes and extend our understanding of their functionally specialized roles.ca
- dc.description.sponsorship This study was funded by a National Health and Medical Research Council of Australia (NHMRC) Project Grant (1064643; Principal Investigator, BJH). CGD was supported by an NHMRC Career Development Fellowship (1061757).
- dc.format.mimetype application/pdfca
- dc.identifier.citation Davey CG, Pujol J, Harrison BJ. Mapping the self in the brain's default mode network. Neuroimage. 2016 May 15;132:390-7. doi: 10.1016/j.neuroimage.2016.02.022ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2016.02.022
- dc.identifier.issn 1053-8119
- dc.identifier.uri http://hdl.handle.net/10230/26230
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Neuroimage. 2016 May 15;132:390-7
- dc.rights © 2016 Elsevier.licensed under the Creative Commmons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://dx.doi.org/10.1016/j.neuroimage.2016.02.022ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ca
- dc.subject.other Cervell -- Fisiologiaca
- dc.subject.other Cervell -- Localització de funcionsca
- dc.title Mapping the self in the brain's default mode networkca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca