Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
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- dc.contributor.author Solé Vicente, Ricard, 1962-ca
- dc.contributor.author Sardanyés i Cayuela, Josepca
- dc.contributor.author Simó, Carlesca
- dc.contributor.author Martínez, Reginaca
- dc.contributor.author Elena, Santiago F.ca
- dc.date.accessioned 2015-06-19T07:18:43Z
- dc.date.available 2015-06-19T07:18:43Z
- dc.date.issued 2014ca
- dc.description.abstract The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a large quasispecies by means of a phenotypic version of the classic Eigen's model that incorporates beneficial, neutral, deleterious, and lethal mutations. By parameterizing the model with available experimental data on the DMFE of Vesicular stomatitis virus (VSV) and Tobacco etch virus (TEV), we found that increasing mutation does not totally push the entire viral quasispecies towards deleterious or lethal regions of the phenotypic sequence space. The probability of finding regions in the parameter space of the general model that results in a quasispecies only composed by lethal phenotypes is extremely small at equilibrium and in transient times. The implications of our findings can be extended to other scenarios, such as lethal mutagenesis or genomically unstable cancer, where increased mutagenesis has been suggested as a potential therapy.en
- dc.description.sponsorship This work was partially funded by the Botín Foundation (JS, RVS), by the Spanish Secretaria de Estado de Investigación, Desarrollo e Innovación grants MTM2010-16425 (CS, RM) and BFU2012-30805 (SFE), by grant 2009-SGR-67 from the Catalan government (CS, RM), by grant NSF PHY05-51164 (JS, SFE), and by the Santa Fe Institute (RVS, SFE).en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Sardanyés J, Simó C, Martínez R, Solé RV, Elena SF. Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations. Scientific Reports. 2014;4:4625. DOI: 10.1038/srep04625ca
- dc.identifier.doi http://dx.doi.org/10.1038/srep04625
- dc.identifier.issn 2045-2322ca
- dc.identifier.uri http://hdl.handle.net/10230/24545
- dc.language.iso engca
- dc.publisher Nature Publishing Groupca
- dc.relation.ispartof Scientific Reports. 2014;4:4625
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/MTM2010-16425
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-30805
- dc.rights © Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images in this article are included in the article's Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the imageen
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/
- dc.subject.keyword Evolutionary theoryen
- dc.subject.keyword Virologyen
- dc.subject.keyword Applied mathematicsen
- dc.subject.other Genèticaca
- dc.subject.other Evolució (Biologia)ca
- dc.title Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populationsen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca