Elemental Constituents of Particulate Matter and Newborn's Size in Eight European Cohorts.

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• dc.contributor.author Pedersen, Marieca
• dc.contributor.author Basagaña Flores, Xavierca
• dc.contributor.author Cirach, Martaca
• dc.contributor.author Sunyer Deu, Jordica
• dc.contributor.author Nieuwenhuijsen, Mark J.ca
• dc.contributor.author Kogevinas, Manolisca
• dc.contributor.author Slama, Rémyca
• dc.date.accessioned 2016-01-08T11:23:29Z
• dc.date.available 2016-01-08T11:23:29Z
• dc.date.issued 2016
• dc.description.abstract BACKGROUND: The health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to chemical constituents of PM and newborn's size have been little examined. OBJECTIVE: We aimed to investigate the associations of exposure to elemental constituents of PM with term low birth weight (LBW; weight < 2,500 g among births after 37 weeks of gestation), mean birth weight, and head circumference, relying on standardized fine-scale exposure assessment and with extensive control for potential confounders. METHODS: We pooled data from eight European cohorts comprising 34,923 singleton births in 1994-2008. Annual average concentrations of elemental constituents of PM ≤ 2.5 and ≤ 10 μm (PM2.5 and PM10) at maternal home addresses during pregnancy were estimated using land-use regression models. Adjusted associations between each birth measurement and concentrations of eight elements (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) were calculated using random-effects regression on pooled data. RESULTS: A 200-ng/m3 increase in sulfur in PM2.5 was associated with an increased risk of LBW (adjusted odds ratio = 1.36; 95% confidence interval: 1.17, 1.58). Increased nickel and zinc in PM2.5 concentrations were also associated with an increased risk of LBW. Head circumference was reduced at higher exposure to all elements except potassium. All associations with sulfur were most robust to adjustment for PM2.5 mass concentration. All results were similar for PM10. CONCLUSION: Sulfur, reflecting secondary combustion particles in this study, may adversely affect LBW and head circumference, independently of particle mass.ca
• dc.description.sponsorship The research leading to these results was funded by the European Community’s Seventh Framework Program (FP7/2007-2011) projects ESCAPE (grant agreement 211250) and TRANSPHORM (ENV.2009.1.2.2.1). M.P. holds a Juan de la Cierva postdoctoral fellowship awarded from the Spanish Ministry of Science and Innovation (JCI-2011-09479).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Pedersen M, Gehring U, Beelen R, Wang M, Giorgis-Allemand L, Andersen AM. Elemental constituents of particulate matter and newborn's size in eight European cohorts. Environ Health Perspect. 2016;124:141-50. DOI: 10.1289/ehp.1409546ca
• dc.identifier.doi http://dx.doi.org/10.1289/ehp.1409546
• dc.identifier.issn 0091-6765
• dc.identifier.uri http://hdl.handle.net/10230/25542
• dc.language.iso engca
• dc.publisher National Institute of Environmental Health Sciences (NIEHS)ca
• dc.relation.ispartof Environmental health perspectives. 2016;124:141-50
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/JCI2011-09479
• dc.rights Reproduced with permission from Environmental Health perspectivesca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.other Medi ambient -- Avaluació del riscca
• dc.subject.other Infants nadonsca
• dc.title Elemental Constituents of Particulate Matter and Newborn's Size in Eight European Cohorts.ca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca