Aberrant repair and fibrosis development in skeletal muscle
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Mann, Christopher J.ca
- dc.contributor.author Perdiguero, Eusebio, 1968-ca
- dc.contributor.author Kharraz, Yacineca
- dc.contributor.author Aguilar, Susanaca
- dc.contributor.author Pessina, Patriziaca
- dc.contributor.author Serrano, Antonio L.ca
- dc.contributor.author Muñoz Cánoves, Pura, 1962-ca
- dc.date.accessioned 2013-06-12T13:33:31Z
- dc.date.available 2013-06-12T13:33:31Z
- dc.date.issued 2011ca
- dc.description.abstract The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals. Following acute tissue injury, infiltrating inflammatory cells and resident stem cells orchestrate their activities to restore tissue homeostasis. However, during chronic tissue damage, such as in muscular dystrophies, the inflammatory-cell infiltration and fibroblast activation persists, while the reparative capacity of stem cells (satellite cells) is attenuated. Abnormal dystrophic muscle repair and its end stage, fibrosis, represent the final common pathway of virtually all chronic neurodegenerative muscular diseases. As our understanding of the pathogenesis of muscle fibrosis has progressed, it has become evident that the muscle provides a useful model for the regulation of tissue repair by the local microenvironment, showing interplay among muscle-specific stem cells, inflammatory cells, fibroblasts and extracellular matrix components of the mammalian wound-healing response. This article reviews the emerging findings of the mechanisms that underlie normal versus aberrant muscle-tissue repair.
- dc.description.sponsorship This work was funded by MICINN (PLE2009-0124, SAF2009-09782, FIS-PS09/01267, SAF2010-21682, CIBERNED), Fundación Marató-TV3/R-Pascual, MDA, EU-FP7 (Myoage, Optistem and Endostem) and AFM.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Mann CJ, Perdiguero E, Kharraz Y, Aguilar S, Pessina P, Serrano AL et al. Aberrant repair and fibrosis development in skeletal muscle. Skelet Muscle. 2011;1(1):21. DOI: 10.1186/2044-5040-1-21ca
- dc.identifier.doi http://dx.doi.org/10.1186/2044-5040-1-21
- dc.identifier.issn 2044-5040ca
- dc.identifier.uri http://hdl.handle.net/10230/20680
- dc.language.iso engca
- dc.publisher BioMed Centralca
- dc.relation.ispartof Skeletal Muscle. 2011;1(1):21
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/PLE2009-0124
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/241440
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/223098
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/223576
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2009-09782
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-21682
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/FIS-PS09/01267
- dc.rights © Mann CJ et al. Creative Commons Attribution License http://creativecommons.org/licenses/by/2.0/ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Malalties neuromusculars
- dc.subject.other Cèl·lules
- dc.subject.other Genètica
- dc.title Aberrant repair and fibrosis development in skeletal muscleca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca