p53 immunohistochemical patterns in HPV-independent squamous cell carcinomas of the vulva and the associated skin lesions: a study of 779 cases

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• dc.contributor.author Rakislova, Natalia
• dc.contributor.author Alemany, Laia
• dc.contributor.author Clavero, Omar
• dc.contributor.author Saco, Adela
• dc.contributor.author Torné, Aureli
• dc.contributor.author Pino, Marta Del
• dc.contributor.author Munmany, Meritxell
• dc.contributor.author Rodrigo Calvo, Maria Teresa
• dc.contributor.author Guerrero, José
• dc.contributor.author Marimon, Lorena
• dc.contributor.author Vega, Naiara
• dc.contributor.author Quirós, Beatriz
• dc.contributor.author Lloveras Rubio, Belen
• dc.contributor.author Ribera-Cortada, Inmaculada
• dc.contributor.author Alejo, María
• dc.contributor.author Pawlita, Michael
• dc.contributor.author Quint, Wim
• dc.contributor.author Sanjosé Llongueras, Silvia de
• dc.contributor.author Ordi, Jaume
• dc.contributor.author Vvap Study Group
• dc.date.accessioned 2021-07-22T07:11:48Z
• dc.date.available 2021-07-22T07:11:48Z
• dc.date.issued 2020
• dc.description.abstract Human papillomavirus (HPV)-independent vulvar squamous cell carcinomas (VSCC) and its precursors frequently harbour TP53 mutations. Recently, six p53 immunohistochemical (IHC) patterns have been defined, which have shown strong correlation with TP53 mutation status. However, few studies have applied this new six-pattern framework and none of them exhaustively compared p53 IHC positivity and patterns between invasive VSCC and adjacent skin lesion. We performed p53 IHC in a series of 779 HPV-independent VSCC with adjacent skin and evaluated the IHC slides following the newly described classification. Some 74.1% invasive VSCC showed abnormal p53 IHC staining. A skin lesion was identified in 450 cases (57.8%), including 254 intraepithelial precursors and 196 inflammatory/reactive lesions. Two hundred and ten of 450 (47%) VSCC with associated skin lesions showed an abnormal p53 IHC stain, with an identical staining pattern between the VSCC and the adjacent skin lesion in 80% of the cases. A total of 144/450 (32%) VSCC showed wild-type p53 IHC both in the invasive VSCC and adjacent skin lesion. Finally, 96/450 (21%) VSCC showed p53 IHC abnormal staining in the invasive VSCC but a wild-type p53 staining in the skin lesion. Most of the discordant cases (70/96; 73%) showed adjacent inflammatory lesions. In conclusion, the p53 IHC staining and pattern are usually identical in the VSCC and the intraepithelial precursor.
• dc.format.mimetype application/pdf
• dc.identifier.citation Rakislova N, Alemany L, Clavero O, Saco A, Torné A, Del Pino M, et al. p53 immunohistochemical patterns in HPV-independent squamous cell carcinomas of the vulva and the associated skin lesions: a study of 779 cases. Int J Mol Sci. 2020 Oct 29;21(21): 8091. DOI: 10.3390/ijms21218091
• dc.identifier.doi http://dx.doi.org/10.3390/ijms21218091
• dc.identifier.issn 1422-0067
• dc.identifier.uri http://hdl.handle.net/10230/48275
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword HPV-independent vulvar cancer
• dc.subject.keyword TP53
• dc.subject.keyword p53
• dc.subject.keyword Vulvar squamous cell carcinoma
• dc.title p53 immunohistochemical patterns in HPV-independent squamous cell carcinomas of the vulva and the associated skin lesions: a study of 779 cases
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion