Comparison between an exact and a heuristic neural mass model with second-order synapses

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  • dc.contributor.author Clusella, Pau
  • dc.contributor.author Köksal-Ersöz, Elif
  • dc.contributor.author García Ojalvo, Jordi
  • dc.contributor.author Ruffini, Giulio
  • dc.date.accessioned 2023-01-16T07:34:33Z
  • dc.date.available 2023-01-16T07:34:33Z
  • dc.date.issued 2023
  • dc.description.abstract Neural mass models (NMMs) are designed to reproduce the collective dynamics of neuronal populations. A common framework for NMMs assumes heuristically that the output firing rate of a neural population can be described by a static nonlinear transfer function (NMM1). However, a recent exact mean-field theory for quadratic integrate-and-fire (QIF) neurons challenges this view by showing that the mean firing rate is not a static function of the neuronal state but follows two coupled nonlinear differential equations (NMM2). Here we analyze and compare these two descriptions in the presence of second-order synaptic dynamics. First, we derive the mathematical equivalence between the two models in the infinitely slow synapse limit, i.e., we show that NMM1 is an approximation of NMM2 in this regime. Next, we evaluate the applicability of this limit in the context of realistic physiological parameter values by analyzing the dynamics of models with inhibitory or excitatory synapses. We show that NMM1 fails to reproduce important dynamical features of the exact model, such as the self-sustained oscillations of an inhibitory interneuron QIF network. Furthermore, in the exact model but not in the limit one, stimulation of a pyramidal cell population induces resonant oscillatory activity whose peak frequency and amplitude increase with the self-coupling gain and the external excitatory input. This may play a role in the enhanced response of densely connected networks to weak uniform inputs, such as the electric fields produced by noninvasive brain stimulation.
  • dc.description.sponsorship This work has received funding from the European Research Council (ERC Synergy) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 855109) and from the Future and Emerging Technologies Programme (FET) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 101017716). J.G.-O. is supported by the Spanish Ministry of Science and Innovation and FEDER (grant PID2021-127311 NB-I00), by the “Maria de Maeztu” Programme for Units of Excellence in R &D (grant CEX2018-000792-M), and by the Generalitat de Catalunya (ICREA Academia programme).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Clusella P, Köksal-Ersöz E, Garcia-Ojalvo J, Ruffini G. Comparison between an exact and a heuristic neural mass model with second-order synapses. Biol Cybern. 2023 Apr;117(1-2):5-19. DOI: 10.1007/s00422-022-00952-7
  • dc.identifier.doi http://dx.doi.org/10.1007/s00422-022-00952-7
  • dc.identifier.issn 0340-1200
  • dc.identifier.uri http://hdl.handle.net/10230/55276
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof Biol Cybern. 2023 Apr;117(1-2):5-19
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/855109
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2021-127311 NB-I00
  • dc.rights © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.title Comparison between an exact and a heuristic neural mass model with second-order synapses
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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