International external validation of risk prediction model of 90-day mortality after gastrectomy for cancer using machine learning

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Dal Cero, Mariagiulia
• dc.contributor.author Gibert Fernandez, Joan, 1988-
• dc.contributor.author Grande Posa, Luís
• dc.contributor.author Gimeno, Marta
• dc.contributor.author Monzonis-Hernández, Xavier
• dc.contributor.author Pera Roman, Manuel Ramón
• dc.date.accessioned 2025-03-14T07:13:29Z
• dc.date.available 2025-03-14T07:13:29Z
• dc.date.issued 2024
• dc.description.abstract Background: Radical gastrectomy remains the main treatment for gastric cancer, despite its high mortality. A clinical predictive model of 90-day mortality (90DM) risk after gastric cancer surgery based on the Spanish EURECCA registry database was developed using a matching learning algorithm. We performed an external validation of this model based on data from an international multicenter cohort of patients. Methods: A cohort of patients from the European GASTRODATA database was selected. Demographic, clinical, and treatment variables in the original and validation cohorts were compared. The performance of the model was evaluated using the area under the curve (AUC) for a random forest model. Results: The validation cohort included 2546 patients from 24 European hospitals. The advanced clinical T- and N-category, neoadjuvant therapy, open procedures, total gastrectomy rates, and mean volume of the centers were significantly higher in the validation cohort. The 90DM rate was also higher in the validation cohort (5.6%) vs. the original cohort (3.7%). The AUC in the validation model was 0.716. Conclusion: The externally validated model for predicting the 90DM risk in gastric cancer patients undergoing gastrectomy with curative intent continues to be as useful as the original model in clinical practice.
• dc.format.mimetype application/pdf
• dc.identifier.citation Dal Cero M, Gibert J, Grande L, Gimeno M, Osorio J, Bencivenga M, et al. International external validation of risk prediction model of 90-day mortality after gastrectomy for cancer using machine learning. Cancers (Basel). 2024 Jul 5;16(13):2463. DOI: 10.3390/cancers16132463
• dc.identifier.doi http://dx.doi.org/10.3390/cancers16132463
• dc.identifier.issn 2072-6694
• dc.identifier.uri http://hdl.handle.net/10230/69934
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Cancers (Basel). 2024 Jul 5;16(13):2463
• dc.rights © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Gastrectomy
• dc.subject.keyword Gastric cancer
• dc.subject.keyword Machine learning
• dc.subject.keyword Mortality
• dc.subject.keyword Prediction
• dc.subject.keyword Validation
• dc.title International external validation of risk prediction model of 90-day mortality after gastrectomy for cancer using machine learning
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion