Metabolomics signatures of exposure to ambient air pollution: A large-scale metabolome-wide association study in the cancer prevention study-II nutrition cohort

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Liang, Donghai
• dc.contributor.author Tang, Ziyin
• dc.contributor.author Diver, W. Ryan
• dc.contributor.author Sarnat, Jeremy A.
• dc.contributor.author Chow, Sabrina S.
• dc.contributor.author Cheng, Haoran
• dc.contributor.author Deubler, Emily L.
• dc.contributor.author Tan, Youran
• dc.contributor.author Eick, Stephanie M.
• dc.contributor.author Jerrett, Michael
• dc.contributor.author Turner, Michelle C.
• dc.contributor.author Wang, Ying
• dc.date.accessioned 2025-02-11T07:23:17Z
• dc.date.available 2025-02-11T07:23:17Z
• dc.date.issued 2025
• dc.description.abstract Existing air pollution metabolomics studies showed inconsistent results, often limited by small sample size and individual air pollutants effects. We conducted a metabolome-wide association study among 1096 women (68.2 ± 5.7 years) who provided blood samples (1998-2001) within the Cancer Prevention Study-II Nutrition Cohort. Annual average individual exposures to particulate matter, nitrogen dioxide, ozone, sulfur dioxide, and carbon monoxide in the year of blood draw were used. Metabolomics profiling was conducted on serum samples by Metabolon. We evaluated the individual air pollutants effects using multiple linear regression and the mixture effect using quantile g-computation, adjusting for confounders and false discovery rate (FDR). Ninety-five metabolites were significantly associated with at least one air pollutant or mixture (FDR < 0.05). These metabolites were enriched in pathways related to oxidative stress, systemic inflammation, energy metabolism, signals transduction, nucleic acid damage and repair, and xenobiotics. Sixty metabolites were confirmed with level 1 or 2 evidence, among which 21 have been previously linked to air pollution exposure, including taurine, creatinine, and sebacate. Overall, our results replicate prior findings in a large sample and provide novel insights into biological responses to long-term air pollution exposure using mixture analysis.
• dc.description.sponsorship The American Cancer Society funds the creation, maintenance, and updating of the Cancer Prevention Study-II cohort. The study was supported by the Emory Human Exposome Research Center (HERCULES), supported by the National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number P30ES019776. The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work was also supported by the National Institute of Health (NIH) research grants [R21ES032117, R01ES035738]. M.C.T. is funded by a Ramón y Cajal fellowship (RYC-2017-01892) from the Spanish Ministry of Science, Innovation and Universities and cofunded by the European Social Fund. ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.
• dc.format.mimetype application/pdf
• dc.identifier.citation Liang D, Tang Z, Diver WR, Sarnat JA, Chow SS, Cheng H, et al. Metabolomics signatures of exposure to ambient air pollution: A large-scale metabolome-wide association study in the cancer prevention study-II nutrition cohort. Environ Sci Technol. 2025 Jan 14;59(1):212-23. DOI: 10.1021/acs.est.4c09592
• dc.identifier.doi http://dx.doi.org/10.1021/acs.est.4c09592
• dc.identifier.issn 0013-936X
• dc.identifier.uri http://hdl.handle.net/10230/69542
• dc.language.iso eng
• dc.publisher American Chemical Society (ACS)
• dc.relation.ispartof Environ Sci Technol. 2025 Jan 14;59(1):212-23
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RYC-2017-01892
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
• dc.rights Copyright © 2024 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0 (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Air pollution
• dc.subject.keyword High-resolution metabolomics
• dc.subject.keyword Inflammation
• dc.subject.keyword Metabolome-wide association study
• dc.subject.keyword Mixture
• dc.subject.keyword Oxidative stress
• dc.title Metabolomics signatures of exposure to ambient air pollution: A large-scale metabolome-wide association study in the cancer prevention study-II nutrition cohort
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion