Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination

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  • dc.contributor.author Sisteré-Oró, Marta
  • dc.contributor.author Du, Juan
  • dc.contributor.author Wortmann, Diana D. J.
  • dc.contributor.author Filippi, Marina D.
  • dc.contributor.author Cañas-Ruano, Esperanza
  • dc.contributor.author Arrieta Aldea, Itziar
  • dc.contributor.author Marcos-Blanco, Agustín
  • dc.contributor.author Castells, Xavier
  • dc.contributor.author Grau Cerrato, Santiago
  • dc.contributor.author García-Giralt, Natalia
  • dc.contributor.author Perez-Zsolt, Daniel
  • dc.contributor.author Boreika, Rytis
  • dc.contributor.author Izquierdo-Useros, Nuria
  • dc.contributor.author Güerri Fernández, Roberto
  • dc.contributor.author Meyerhans, Andreas
  • dc.date.accessioned 2024-04-12T05:42:12Z
  • dc.date.available 2024-04-12T05:42:12Z
  • dc.date.issued 2024
  • dc.description.abstract People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan-pox-specific T-cell responses in a cohort of HIV-1-infected individuals after receiving the nonreplicative, attenuated smallpox vaccine JYNNEOS from Bavarian Nordic. Intradermal (i.d.) and subcutaneous (s.c.) vaccination was safe without major side effects. Dose-sparing i.d. vaccination was superior to s.c. vaccination and promoted T-cell polyfunctionality, and the expression of the gut-homing marker α4β7 integrin on lymphocytes. HIV-1-infected individuals with CD4 T-cell counts ≤500/mm3 blood required at least a booster vaccination to exhibit efficient virus-specific T-cell responses. The magnitude of the Th1 response after this booster directly correlated with the CD4 T-cell count of the vaccinees. Further studies with a larger number of participants are warranted to confirm and expand our observations.
  • dc.description.sponsorship This work received support and funding from Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES) (grant number CB16/10/00245), Centro de Investigación Biomédica en Red Enfermedades Infecciosas, CIBERINFEC (CB21/13/00002), FEDER funds, FIS Project “PI19/00019” funded by Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union, the Spanish Ministry of Science and Innovation grant number PID2022-141395OB-I00, and the “Unidad de Excelencia María de Maeztu,” funded by the MCIN and the AEI (DOI: 10.13039/501100011033). Nuria Izquierdo-Useros is supported by the Spanish Ministry of Science and Innovation (grant PID2020-117145RB-I00, Spain), EU HORIZON-HLTH-2021CORONA-01 (grant 101046118, European Union).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Sisteré-Oró M, Du J, Wortmann DDJ, Filippi MD, Cañas-Ruano E, Arrieta-Aldea I, et al. Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination. J Med Virol. 2024 Jan;96(1):e29317. DOI: 10.1002/jmv.29317
  • dc.identifier.doi http://dx.doi.org/10.1002/jmv.29317
  • dc.identifier.issn 0146-6615
  • dc.identifier.uri http://hdl.handle.net/10230/59743
  • dc.language.iso eng
  • dc.publisher Wiley
  • dc.relation.ispartof J Med Virol. 2024 Jan;96(1):e29317
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101046118
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-141395OB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-117145RB-I00
  • dc.rights © 2023 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword HIV-1-infected individuals
  • dc.subject.keyword JYNNEOS vaccination
  • dc.subject.keyword Monkeypox (mpox)
  • dc.subject.keyword Pan-pox-specific T-cell responses
  • dc.title Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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