Genome-wide transcriptomic changes reveal the genetic pathways involved in insect migration

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• dc.contributor.author Doyle, Toby
• dc.contributor.author Jiménez Guri, Eva
• dc.contributor.author Hawkes, Will L.S.
• dc.contributor.author Massy, Richard
• dc.contributor.author Mantica, Federica
• dc.contributor.author Permanyer, Jon
• dc.contributor.author Cozzuto, Luca
• dc.contributor.author Hermoso Pulido, Antonio
• dc.contributor.author Baril, Tobias
• dc.contributor.author Hayward, Alexander
• dc.contributor.author Irimia Martínez, Manuel
• dc.contributor.author Chapman, Jason W.
• dc.contributor.author Bass, Chris
• dc.contributor.author Wotton, Karl R.
• dc.date.accessioned 2022-11-03T07:10:31Z
• dc.date.available 2022-11-03T07:10:31Z
• dc.date.issued 2022
• dc.description.abstract Insects are capable of extraordinary feats of long-distance movement that have profound impacts on the function of terrestrial ecosystems. The ability to undertake these movements arose multiple times through the evolution of a suite of traits that make up the migratory syndrome, however the underlying genetic pathways involved remain poorly understood. Migratory hoverflies (Diptera: Syrphidae) are an emerging model group for studies of migration. They undertake seasonal movements in huge numbers across large parts of the globe and are important pollinators, biological control agents and decomposers. Here, we assembled a high-quality draft genome of the marmalade hoverfly (Episyrphus balteatus). We leveraged this genomic resource to undertake a genome-wide transcriptomic comparison of actively migrating Episyrphus, captured from a high mountain pass as they flew south to overwinter, with the transcriptomes of summer forms which were non-migratory. We identified 1543 genes with very strong evidence for differential expression. Interrogation of this gene set reveals a remarkable range of roles in metabolism, muscle structure and function, hormonal regulation, immunity, stress resistance, flight and feeding behaviour, longevity, reproductive diapause and sensory perception. These features of the migrant phenotype have arisen by the integration and modification of pathways such as insulin signalling for diapause and longevity, JAK/SAT for immunity, and those leading to octopamine production and fuelling to boost flight capabilities. Our results provide a powerful genomic resource for future research, and paint a comprehensive picture of global expression changes in an actively migrating insect, identifying key genomic components involved in this important life-history strategy.
• dc.format.mimetype application/pdf
• dc.identifier.citation Doyle T, Jimenez-Guri E, Hawkes WLS, Massy R, Mantica F, Permanyer J, Cozzuto L, Hermoso Pulido T, Baril T, Hayward A, Irimia M, Chapman JW, Bass C, Wotton KR. Genome-wide transcriptomic changes reveal the genetic pathways involved in insect migration. Mol Ecol. 2022 Aug;31(16):4332-50. DOI: 10.1111/mec.16588
• dc.identifier.doi http://dx.doi.org/10.1111/mec.16588
• dc.identifier.issn 0962-1083
• dc.identifier.uri http://hdl.handle.net/10230/54665
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Mol Ecol. 2022 Aug;31(16):4332-50
• dc.rights © 2022 The Authors. Molecular Ecology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Differential gene expression
• dc.subject.keyword Genetics of migration
• dc.subject.keyword Insect migration
• dc.subject.keyword Migratory hoverflies
• dc.subject.keyword Molecular adaptations
• dc.subject.keyword Syrphidae
• dc.title Genome-wide transcriptomic changes reveal the genetic pathways involved in insect migration
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion