Long-term Impact of Continuous Positive Airway Pressure Therapy on Arrhythmia and Heart Rate Variability in Patients With Sleep Apnea.
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- dc.contributor.author Grau Sanmartí, Nuriaca
- dc.contributor.author Bazán, Víctorca
- dc.contributor.author Kallouchi, Mohamedca
- dc.contributor.author Rodríguez, Diegoca
- dc.contributor.author Estirado Vera, Cristina, 1968-ca
- dc.contributor.author Corral Celma, María Isabelca
- dc.contributor.author Valls Córdoba, Maria Teresaca
- dc.contributor.author Ramos Ardanaz, Pabloca
- dc.contributor.author Sanjuas Benito, Carlosca
- dc.contributor.author Félez Flor, Miguel Ángelca
- dc.contributor.author Vallés Gras, Ermengolca
- dc.contributor.author Benito Villabriga, Begoñaca
- dc.contributor.author Gea Guiral, Joaquimca
- dc.contributor.author Bruguera-Cortada, Jordica
- dc.contributor.author Martí-Almor, Julioca
- dc.date.accessioned 2016-02-25T09:50:05Z
- dc.date.available 2017-01-31T03:00:05Z
- dc.date.issued 2016
- dc.description.abstract INTRODUCTION: Autonomic dysfunction can alter heart rate variability and increase the incidence of arrhythmia. We analyzed the impact of continuous positive airway pressure (CPAP) on this pathophysiological phenomenon in patients with severe sleep apnea-hypopnea syndrome. METHODS: Consecutive patients with recently diagnosed severe sleep apnea-hypopnea syndrome were prospectively considered for inclusion. Incidence of arrhythmia and heart rate variability (recorded on a 24-hour Holter monitoring device) were analyzed before starting CPAP therapy and 1 year thereafter. RESULTS: A total of 26 patients were included in the study. CPAP was administered for 6.6±1.8hours during Holter monitoring. After starting CPAP, we observed a marginally significant reduction in mean HR (80±9 to 77±11 bpm, p=.05). CPAP was associated with partial modulation (only during waking hours) of r-MSSD (p=.047) and HF (p=.025) parasympathetic parameters and LF (p=.049) sympathetic modulation parameters. None of these parameters returned completely to normal levels (p<.001). The number of unsustained episodes of atrial tachycardia diminished (p=.024), but no clear effect on other arrhythmias was observed. CONCLUSIONS: CPAP therapy only partially improves heart rate variability, and exclusively during waking hours, and reduces incidence of atrial tachycardia, both of which can influence cardiovascular morbidity and mortality in sleep apnea-hypopnea syndrome patients.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Grau N, Bazan V, Kallouchi M, Rodriguez D, Estirado C, Corral MI. et al. Long-term Impact of Continuous Positive Airway Pressure Therapy on Arrhythmia and Heart Rate Variability in Patients With Sleep Apnea. Arch Bronconeumol. 2016 Jan;52(1):17-23. doi: 10.1016/j.arbres.2015.03.008.ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.arbres.2015.03.008
- dc.identifier.issn 0300-2896
- dc.identifier.uri http://hdl.handle.net/10230/25944
- dc.language.iso engen
- dc.publisher Elsevierca
- dc.relation.ispartof Archivos de Bronconeumología. 2016 Jan;52(1):17-23
- dc.rights © Copyright 2016. Grau N, Bazan V, Kallouchi M, Rodriguez D, Estirado C, Corral MI. et al. Long-term Impact of Continuous Positive Airway Pressure Therapy on Arrhythmia and Heart Rate Variability in Patients With Sleep Apnea. Arch Bronconeumol. 2016 Jan;52(1):17-23. The definitive versión is available online at http://dx.doi.org/10.1016/j.arbres.2015.03.008ca
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Arrítmiaca
- dc.subject.other Cor -- Batecsca
- dc.title Long-term Impact of Continuous Positive Airway Pressure Therapy on Arrhythmia and Heart Rate Variability in Patients With Sleep Apnea.ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca