Assessing effectiveness of colonic and gynecological risk reducing surgery in Lynch Syndrome individuals

Dueñas, Nuria; Navarro, Matilde; Teulé, Alexandre; Solanes, Ares; Salinas, Mònica; Iglesias, Sílvia; Munté, Elisabet; Ponce, Jordi; Guardiola, Jordi; Kreisler, Esther; Carballas, Elvira; Cuadrado, Marta; Matias-Guiu, Xavier; de la Ossa, Napoleón; Lop Gros, Joan; Lázaro García, Conxi; Capellá, Gabriel; Pineda, Marta; Brune, Joan

Assessing effectiveness of colonic and gynecological risk reducing surgery in Lynch Syndrome individuals

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dc.contributor.author Dueñas, Nuria
dc.contributor.author Navarro, Matilde
dc.contributor.author Teulé, Alexandre
dc.contributor.author Solanes, Ares
dc.contributor.author Salinas, Mònica
dc.contributor.author Iglesias, Sílvia
dc.contributor.author Munté, Elisabet
dc.contributor.author Ponce, Jordi
dc.contributor.author Guardiola, Jordi
dc.contributor.author Kreisler, Esther
dc.contributor.author Carballas, Elvira
dc.contributor.author Cuadrado, Marta
dc.contributor.author Matias-Guiu, Xavier
dc.contributor.author de la Ossa, Napoleón
dc.contributor.author Lop Gros, Joan
dc.contributor.author Lázaro García, Conxi
dc.contributor.author Capellá, Gabriel
dc.contributor.author Pineda, Marta
dc.contributor.author Brune, Joan
dc.date.accessioned 2021-06-07T07:30:45Z
dc.date.available 2021-06-07T07:30:45Z
dc.date.issued 2020
dc.description.abstract Background: Colorectal (CRC) and endometrial cancer (EC) are the most common types of cancer in Lynch syndrome (LS). Risk reducing surgeries (RRS) might impact cancer incidence and mortality. Our objectives were to evaluate cumulative incidences of CRC, gynecological cancer and all-cause mortality after RRS in LS individuals. Methods: Retrospective analysis of 976 LS carriers from a single-institution registry. Primary endpoints were cumulative incidence at 75 years of cancer (metachronous CRC in 425 individuals; EC and ovarian cancer (OC) in 531 individuals) and all-cause mortality cumulative incidence, comparing extended (ES) vs. segmental surgery (SS) in the CRC cohort and risk reducing gynecological surgery (RRGS) vs. surveillance in the gynecological cohort. Results: Cumulative incidence at 75 years of metachronous CRC was 12.5% vs. 44.7% (p = 0.04) and all-cause mortality cumulative incidence was 38.6% vs. 55.3% (p = 0.31), for ES and SS, respectively. Cumulative, incidence at 75 years was 11.2% vs. 46.3% for EC (p = 0.001) and 0% vs. 12.7% for OC (p N/A) and all-cause mortality cumulative incidence was 0% vs. 52.7% (p N/A), for RRGS vs. surveillance, respectively. Conclusions: RRS in LS reduces the incidence of metachronous CRC and gynecological neoplasms, also indicating a reduction in all-cause mortality cumulative incidence in females undergoing RRGS.
dc.description.sponsorship This research has been funded by the Instituto de Salud Carlos III and co-funded by European Social Fund—ESF investing in your future—(grant CM19/00099), the Catalan-Balearic Society of Oncology (2018 grant of the Catalan-Balearic Society of Oncology), the Spanish Ministry of Economy and Competitiveness and co-funded by FEDER funds—A way to build Europe—(grant SAF2015-68016-R), CIBERONC and the Government of Catalonia (grants 2017SGR1282 and PERIS SLT002/16/0037). We thank the CERCA Program/Generalitat de Catalunya for institutional support.
dc.format.mimetype application/pdf
dc.identifier.citation Dueñas N, Navarro M, Teulé À, Solanes A, Salinas M, Iglesias S, et al. Assessing effectiveness of colonic and gynecological risk reducing surgery in Lynch Syndrome individuals. Cancers (Basel). 2020 Nov 18; 12(11): 3419. DOI: 10.3390/cancers12113419
dc.identifier.doi http://dx.doi.org/10.3390/cancers12113419
dc.identifier.issn 2072-6694
dc.identifier.uri http://hdl.handle.net/10230/47777
dc.language.iso eng
dc.publisher MDPI
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015-68016-R
dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Lynch syndrome
dc.subject.keyword Colorectal neoplasms
dc.subject.keyword Endometrial neoplasms
dc.subject.keyword Gynecological neoplasms
dc.subject.keyword Ovarian neoplasms
dc.subject.keyword Prophylactic surgical procedures
dc.subject.keyword Risk reducing surgery
dc.subject.keyword Risk reduction
dc.title Assessing effectiveness of colonic and gynecological risk reducing surgery in Lynch Syndrome individuals
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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