X-inactivation: quantitative predictions of protein interactions in the Xist network

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Agostini, Federico, 1985-ca
• dc.contributor.author Cirillo, Davideca
• dc.contributor.author Bolognesi, Benedettaca
• dc.contributor.author Tartaglia, Gian Gaetanoca
• dc.date.accessioned 2014-06-03T07:23:31Z
• dc.date.available 2014-06-03T07:23:31Z
• dc.date.issued 2013ca
• dc.description.abstract The transcriptional silencing of one of the female X-chromosomes is a finely regulated process that requires accumulation in cis of the long non-coding RNA X-inactive-specific transcript (Xist) followed by a series of epigenetic modifications. Little is known about the molecular machinery regulating initiation and maintenance of chromosomal silencing. Here, we introduce a new version of our algorithm catRAPID to investigate Xist associations with a number of proteins involved in epigenetic regulation, nuclear scaffolding, transcription and splicing processes. Our method correctly identifies binding regions and affinities of protein interactions, providing a powerful theoretical framework for the study of X-chromosome inactivation and other events mediated by ribonucleoprotein associations.
• dc.description.sponsorship Funding for open access charge: Spanish Ministry of Economy and Competitiveness [SAF2011-26211]
• dc.format.mimetype application/pdfca
• dc.identifier.citation Agostini F, Cirillo D, Bolognesi B, Tartaglia GG. X-inactivation: quantitative predictions of protein interactions in the Xist network. Nucleic Acids Res. 2013; 41(1): e31. DOI: 10.1093/nar/gks968ca
• dc.identifier.doi http://dx.doi.org/10.1093/nar/gks968
• dc.identifier.issn 0305-1048ca
• dc.identifier.uri http://hdl.handle.net/10230/22553
• dc.language.iso engca
• dc.publisher Oxford University Pressca
• dc.relation.ispartof Nucleic Acids Research. 2013;41(1):e31
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-26211
• dc.rights © 2013 Federico Agostini et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of a Creative Commons Attribution Licenseca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
• dc.subject.other Algoritmes
• dc.subject.other Cromosoma X
• dc.subject.other RNA
• dc.title X-inactivation: quantitative predictions of protein interactions in the Xist networkca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca