The hypocretin/orexin system: implications for drug reward and relapse

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• dc.contributor.author Plaza-Zabala, Ainhoa, 1982-ca
• dc.contributor.author Maldonado, Rafael, 1961-ca
• dc.contributor.author Berrendero Díaz, Fernando, 1971-ca
• dc.date.accessioned 2015-03-27T08:00:50Z
• dc.date.available 2015-03-27T08:00:50Z
• dc.date.issued 2012ca
• dc.description.abstract Hypocretins (also known as orexins) are hypothalamic neuropeptides involved in the regulation of sleep/wake states and feeding behavior. Recent studies have also demonstrated an important role for the hypocretin/orexin system in the addictive properties of drugs of abuse, consistent with the reciprocal innervations between hypocretin neurons and brain areas involved in reward processing. This system participates in the primary reinforcing effects of opioids, nicotine, and alcohol. Hypocretins are also involved in the neurobiological mechanisms underlying relapse to drug-seeking behavior induced by drug-related environmental stimuli and stress, as mainly described in the case of psychostimulants. Based on these preclinical studies, the use of selective ligands targeting hypocretin receptors could represent a new therapeutical strategy for the treatment of substance abuse disorders. In this review, we discuss and update the current knowledge about the participation of the hypocretin system in drug addiction and the possible neurobiological mechanisms involved in these processes regulated by hypocretin transmission.
• dc.description.sponsorship This work was supported by the Instituto de Salud Carlos III grants #PI07/0559,/n#PI10/00316, and #RD06/001/001 (RTA-RETICS), by the Spanish Ministry of Science/nand Technology (Consolider-C, #SAF2007-64062), the Catalan Government/n(SGR2009-00731), and by the Catalan Institution for Research and Advanced Studies/n(ICREA Academia program). A Plaza-Zabala is a recipient of a predoctoral fellowship/nfrom the Spanish Ministry of Education.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Plaza-Zabala A, Maldonado R, Berrendero F. The hypocretin/orexin system: implications for drug reward and relapse. Mol Neurobiol. 2012 Jun;45(3):424-39. DOI: 10.1007/s12035-012-8255-zca
• dc.identifier.doi http://dx.doi.org/10.1007/s12035-012-8255-z
• dc.identifier.issn 0893-7648ca
• dc.identifier.uri http://hdl.handle.net/10230/23296
• dc.language.iso engca
• dc.publisher Springerca
• dc.relation.ispartof Molecular Neurobiology. 2012 Jun;45(3):424-39
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2007-64062
• dc.rights © Springer (The original publication is available at www.springerlink.com)ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.other Pèptids
• dc.subject.other Proteïnes
• dc.subject.other Neuropèptids
• dc.subject.other Abús de substàncies
• dc.title The hypocretin/orexin system: implications for drug reward and relapseca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/acceptedVersionca