One abnormal value or vomiting after oral glucose tolerance test in pregnancy: incidence and impact on maternal-fetal outcomes

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• dc.contributor.author Navarro Martínez, Humberto
• dc.contributor.author Flores-Le-Roux, Juana Antonia
• dc.contributor.author Llauradó Cabot, Gemma
• dc.contributor.author Gortazar, Lucía
• dc.contributor.author Payà Panadés, Antonio
• dc.contributor.author Mañé, Laura
• dc.contributor.author Pedro-Botet, Juan Carlos
• dc.contributor.author Benaiges Foix, David
• dc.date.accessioned 2024-03-19T07:33:51Z
• dc.date.available 2024-03-19T07:33:51Z
• dc.date.issued 2023
• dc.description.abstract Objective: To analyze pregnancy outcomes of women with one abnormal value (OAV) during oral glucose tolerance test (OGTT) or OGTT-intolerance, compared with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT) pregnant women, according to whether they received any health intervention or not. Methods: An observational retrospective study was designed including pregnant women who gave birth at Hospital del Mar, Barcelona (Spain) during December/2014-July/2018. Baseline characteristics, pregnancy outcomes and health interventions were obtained from a database collected previously for other study. Inclusion criteria were singleton pregnancies with OAV or OGTT-intolerants who gave birth at the Hospital. GDM screening followed a two-step approach: 50 g O'Sullivan test and 100 g 3-hour OGTT if the former was abnormal. Results: From a total of 2,662 pregnancies, 326 (12.2%) had GDM, 87 OAV (3.3%), 65 OGTT intolerance (2.4%) and 2,184 were NGT women. First trimester HbA1c in both OAV and OGTT-intolerant women was significantly higher than in NGT group, and significantly lower than in GDM pregnants. No differences in obstetric outcomes were found between OGTT-intolerants and NGT/GDM groups. Treated OGTT-intolerants had greater gestational age at delivery than non-treated ones (weeks, 39.6 ± 1.2 vs 38.0 ± 4.0, respectively). In OAV women, significant differences were observed in newborns' birthweight (g, 3227.3 ± 500.8 vs 3351.1 ± 436.7, vs GDM) and gestational age at birth (weeks, 38.7 ± 1.8 vs 39.3 ± 1.9, vs NGT), but not in macrosomia/pre-eclampsia. No differences were found according to treatment in OAV. Conclusions: OAV and OGTT-intolerants account for a third of pregnant women referred to Diabetes Unit. Their rates of preterm birth, pre-eclampsia and macrosomia were not different from NGT or GDM women.
• dc.format.mimetype application/pdf
• dc.identifier.citation Navarro-Martinez H, Flores-Le Roux JA, Llauradó G, Gortazar L, Payà A, Mañé L, et al. One abnormal value or vomiting after oral glucose tolerance test in pregnancy: incidence and impact on maternal-fetal outcomes. Gynecol Endocrinol. 2023 Dec;39(1):2242951. DOI: 10.1080/09513590.2023.2242951
• dc.identifier.doi http://dx.doi.org/10.1080/09513590.2023.2242951
• dc.identifier.issn 0951-3590
• dc.identifier.uri http://hdl.handle.net/10230/59481
• dc.language.iso eng
• dc.publisher Taylor & Francis
• dc.relation.ispartof Gynecol Endocrinol. 2023 Dec;39(1):2242951
• dc.rights © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword OGTT-intolerance
• dc.subject.keyword One abnormal value
• dc.subject.keyword Gestational diabetes mellitus
• dc.subject.keyword Oral glucose tolerance test
• dc.subject.keyword Outcomes
• dc.subject.keyword Pregnancy
• dc.subject.keyword Vomiting
• dc.title One abnormal value or vomiting after oral glucose tolerance test in pregnancy: incidence and impact on maternal-fetal outcomes
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion