Does the Mediterranean diet counteract the adverse effects of abdominal adiposity?

Eguaras, Sonia; Toledo, Estefania; Buil-Cosiales, Pilar; Salas-Salvadó, Jordi; Corella, Dolores; Gutierrez-Bedmar, Mario; Santos-Lozano, José; Arós, Fernando; Fiol, Miquel; Fitó Colomer, Montserrat; Ros, Emilio; Serra-Majem, Luis; Pinto, Xavier; Martínez, José Alfredo; Sorlí, José Vicente; Muñoz, Miguel Ángel; Basora, Josep; Estruch, Ramón; Martínez-González, Miguel Ángel, 1957-; PREDIMED investigators

Does the Mediterranean diet counteract the adverse effects of abdominal adiposity?

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dc.contributor.author Eguaras, Soniaca
dc.contributor.author Toledo, Estefaniaca
dc.contributor.author Buil-Cosiales, Pilarca
dc.contributor.author Salas-Salvadó, Jordica
dc.contributor.author Corella, Doloresca
dc.contributor.author Gutierrez-Bedmar, Marioca
dc.contributor.author Santos-Lozano, Joséca
dc.contributor.author Arós, Fernandoca
dc.contributor.author Fiol, Miquelca
dc.contributor.author Fitó Colomer, Montserratca
dc.contributor.author Ros, Emilioca
dc.contributor.author Serra-Majem, Luisca
dc.contributor.author Pinto, Xavierca
dc.contributor.author Martínez, José Alfredoca
dc.contributor.author Sorlí, José Vicenteca
dc.contributor.author Muñoz, Miguel Ángelca
dc.contributor.author Basora, Josepca
dc.contributor.author Estruch, Ramónca
dc.contributor.author Martínez-González, Miguel Ángel, 1957-ca
dc.contributor.author PREDIMED investigatorsca
dc.date.accessioned 2016-01-27T10:58:13Z
dc.date.available 2016-06-30T02:00:04Z
dc.date.issued 2015
dc.description.abstract BACKGROUND AND AIM: We tested the hypothesis that an intervention with a Mediterranean diet (MeDiet) could mitigate the well-known harmful effects of abdominal obesity on cardiovascular health. METHODS AND RESULTS: We assessed the relationship between baseline waist-to-height ratio (WHtR) and major cardiovascular events during a median follow-up of 4.8 years in the Prevention with Mediterranean Diet (PREDIMED) randomized primary prevention trial, which tested a MeDiet against a control diet (advice on a low-fat diet). We also examined whether the MeDiet intervention was able to counteract the detrimental cardiovascular effects of an increased WHtR. The trial included 7447 participants (55-80 years old, 57% women) at high cardiovascular risk but free of cardiovascular disease (CVD) at enrollment. An increased risk of CVD events (myocardial infarction, stroke, or cardiovascular death) was apparent for the highest versus the lowest quartile of WHtR (multivariable-adjusted hazard ratio: 1.98) (95% confidence interval: 1.10-3.57; linear trend: p = 0.019) only in the control-diet group, but not in the two groups allocated to intervention with MeDiet (p for interaction = 0.034). This apparent interaction suggesting that the intervention counterbalanced the detrimental cardiovascular effects of adiposity was also significant for body mass index (BMI) (p = 0.01) and waist circumference (p = 0.043). CONCLUSIONS: The MeDiet may counteract the harmful effects of increased adiposity on the risk of CVD.ca
dc.description.sponsorship Supported by the official funding agency for biomedical research of the Spanish government, Instituto de Salud Carlos III (ISCIII), through specific grants (RTIC G03/140; RTIC-RD 06/0045, to Prof. Martínez-González and CIBERobn), and by Fondo de Investigación Sanitaria eISCIII (PI04-2239, PI05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, and/nP11/02505), Ministerio Ciencia e Innovación (AGL-2009-13906-C02 and AGL2010-22319-C03), Fundación Mapfre 2010, Consejería Salud Junta de Andalucía (PI0105/2007), Health Department of Catalonia, Generalitat Valenciana (ACOMP06109, GVACOMP2010-181, GVACOMP2011-151, CS2010-AP-111, and CS2011-AP-042), and Regional Government of Navarra (P27/2011). ET is supported by a Rio Hortega post-residency fellow of the ISCIII
dc.format.mimetype application/pdfca
dc.identifier.citation Eguaras S, Toledo E, Buil-Cosiales P, Salas-Salvadó J, Corella D, Gutierrez-Bedmar M. et al. Does the Mediterranean diet counteract the adverse effects of abdominal adiposity?. Nutr Metab Cardiovasc Dis. 2015 Jun;25(6):569-74. doi: 10.1016/j.numecd.2015.03.001ca
dc.identifier.doi http://dx.doi.org/10.1016/j.numecd.2015.03.001
dc.identifier.issn 0939-4753
dc.identifier.uri http://hdl.handle.net/10230/25665
dc.language.iso engca
dc.publisher Elsevierca
dc.relation.ispartof Nutrition, Metabolism & Cardiovascular Diseases. 2015 Jun;25(6):569-74
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2010-22319
dc.rights Copyright © 2015 Elsevier B.V. All rights reserved.lsevier has partnered with Copyright Clearance Center's RightsLink service to offer a variety of options for reusing Elsevier content. Select the "I would like to ..." drop-down menu to view the many reuse options available to you.ca
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.other Sistema cardiovascular -- Malaltiesca
dc.subject.other Dieta -- Mediterrània, Regió de laca
dc.title Does the Mediterranean diet counteract the adverse effects of abdominal adiposity?ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/acceptedVersionca

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