Quality of life in a cohort of 1078 women diagnosed with breast cancer in spain: 7-year follow-up results in the MCC-Spain Study

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• dc.contributor.author Alonso Molero, Jessica
• dc.contributor.author Castaño Vinyals, Gemma
• dc.contributor.author Castells, Xavier
• dc.contributor.author Kogevinas, Manolis
• dc.contributor.author Llorca, Javier
• dc.date.accessioned 2021-07-20T06:29:21Z
• dc.date.available 2021-07-20T06:29:21Z
• dc.date.issued 2020
• dc.description.abstract Breast cancer is the most frequent cause of tumors and net survival is increasing. Achieving a higher survival probability reinforces the importance of studying health-related quality of life (HR-QoL). The main aim of this work is to test the relationship between different sociodemographic, clinical and tumor-intrinsic characteristics, and treatment received with HR-QoL measured using SF-12 and the FACT/NCCN (National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy) Breast Symptom Index (FBSI). Women with breast cancer recruited between 2008 and 2013 and followed-up until 2017-2018 in a prospective cohort answered two HR-QoL surveys: the SF-12 and FBSI. The scores obtained were related to woman and tumor characteristics using linear regression models. The telephone survey was answered by 1078 women out of 1685 with medical record follow-up (64%). Increases in all three HR-QoL scores were associated with higher educational level. The score differences between women with university qualifications and women with no schooling were 5.43 for PCS-12, 6.13 for MCS-12 and 4.29 for FBSI. Histological grade at diagnosis and recurrence in the follow-up displayed a significant association with mental and physical HR-QoL, respectively. First-line treatment received was not associated with HR-QoL scores. On the other hand, most tumor characteristics were not associated with HR-QoL. As breast cancer survival is improving, further studies are needed to ascertain if these differences still hold in the long run.
• dc.format.mimetype application/pdf
• dc.identifier.citation Alonso-Molero J, Dierssen-Sotos T, Gomez-Acebo I, Fernandez de Larrea Baz N, Guevara M, Amiano P, et al. Quality of life in a cohort of 1078 women diagnosed with breast cancer in spain: 7-year follow-up results in the MCC-Spain Study. Int J Environ Res Public Health. 2020 Nov 13; 17(22): 8411. DOI: 10.3390/ijerph17228411
• dc.identifier.doi http://dx.doi.org/10.3390/ijerph17228411
• dc.identifier.issn 1660-4601
• dc.identifier.uri http://hdl.handle.net/10230/48234
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword FBSI
• dc.subject.keyword SF-12
• dc.subject.keyword Breast cancer
• dc.subject.keyword Educational level
• dc.subject.keyword Quality of life
• dc.title Quality of life in a cohort of 1078 women diagnosed with breast cancer in spain: 7-year follow-up results in the MCC-Spain Study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion