The effect of tea consumption on the steroid profile

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• dc.contributor.author Coll, Sergi
• dc.contributor.author Matabosch Geronès, Xavier
• dc.contributor.author Garrostas, Lorena
• dc.contributor.author Monfort Mercader, Núria, 1983-
• dc.contributor.author Perez-Maña, Clara
• dc.contributor.author Pizarro Lozano, Mª Nieves
• dc.contributor.author Mateus Rodriguez, Julian Andrés
• dc.contributor.author Ezzel, Mohammed
• dc.contributor.author Torre Fornell, Rafael de la
• dc.contributor.author Ventura Alemany, Rosa
• dc.date.accessioned 2019-04-03T07:30:42Z
• dc.date.issued 2018
• dc.description.abstract Green tea (GT), along with its flavonol epigallocatechin-3-gallate (EGCG), has shown to inhibit the UGT2B17 isoenzyme, which is highly involved in the glucuronidation of testosterone (T) and its metabolites. Since the steroid profile (SP) is composed of urinary concentrations of T and related metabolites excreted in both the free and the glucuronide fractions, GT consumption could alter the SP, leading to misunderstanding in doping controls. The aim of the present work was to study the effect of GT consumption on the SP. This study was performed with 29 male volunteers, which could be classified in 2 arms depending on their T/E values (0.12 ± 0.02, n = 12; 1.64 ± 0.90, n = 17). The clinical protocol was designed to evaluate the effect of GT administration on the SP biomarkers. Participants were asked to consume GT with a high content of EGCG for 7 days (5 GT beverages along the whole day for days 1-6 and 9 GT beverages on day 7, corresponding to 520 and 936 mg/day of EGCG, respectively). Urine samples were collected before and during GT consumption at different time periods. The SP was measured using gas chromatography-mass spectrometry. The excretion rates of the SP metabolites did not change after GT consumption. Moreover, the individual evaluation of the subject's steroidal biological passport resulted in normal sequences. The results obtained show that GT consumption does not distort the establishment of normal ranges of SP parameters. Therefore, GT consumption does not need to be considered a confounding factor in the SP evaluation.
• dc.format.mimetype application/pdf
• dc.identifier.citation Coll S, Matabosch X, Garrostas L, Monfort N, Perez-Maña C, Pizarro N, Mateus JA, Ezzel M, de la Torre R, Ventura R. The effect of tea consumption on the steroid profile. Drug Test Anal. 2018; 10(9):1438-1447. DOI 10.1002/dta.2392
• dc.identifier.doi http://dx.doi.org/10.1002/dta.2392
• dc.identifier.issn 1942-7603
• dc.identifier.uri http://hdl.handle.net/10230/37026
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Drug Testing and Analysis. 2018; 10(9):1438-47
• dc.rights This is the peer reviewed version of the following article: Coll S, Matabosch X, Garrostas L, Monfort N, Perez-Maña C, Pizarro N, Mateus JA, Ezzel M, de la Torre R, Ventura R. The effect of tea consumption on the steroid profile. Drug Test Anal. 2018; 10(9):1438-1447. DOI 10.1002/dta.2392, which has been published in final form at http://dx.doi.org/10.1002/dta.2392. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Doping
• dc.subject.keyword EAAS
• dc.subject.keyword EGCG
• dc.subject.keyword Green tea
• dc.subject.keyword Steroid profile
• dc.subject.other Te -- Alimentació
• dc.title The effect of tea consumption on the steroid profile
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion