Peripheral neutrophil-to-lymphocyte ratio in bronchiectasis. A marker of disease severity
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- dc.contributor.author Martínez-García, Miguel Ángel
- dc.contributor.author Olveira, Casilda
- dc.contributor.author Girón, Rosa
- dc.contributor.author García-Clemente, Marta
- dc.contributor.author Maíz, Luis
- dc.contributor.author Sibila, Oriol
- dc.contributor.author Golpe, Rafael
- dc.contributor.author Méndez, Raúl
- dc.contributor.author Rodriguez, Juan Luis
- dc.contributor.author Barreiro Portela, Esther
- dc.contributor.author Prados, Concepción
- dc.contributor.author Rodríguez-López, Juan
- dc.contributor.author Rosa, David de la
- dc.date.accessioned 2023-02-23T07:43:38Z
- dc.date.available 2023-02-23T07:43:38Z
- dc.date.issued 2022
- dc.description.abstract Most patients with bronchiectasis have a predominantly neutrophilic inflammatory profile, although other cells such as lymphocytes (as controllers of bronchial inflammation) and eosinophils also play a significant pathophysiological role. Easy-to-interpret blood biomarkers with a discriminative capacity for severity or prognosis are needed. The objective of this study was to assess whether the peripheral neutrophil-to-lymphocyte ratio (NLR) is associated with different outcomes of severity in bronchiectasis. A total of 1369 patients with bronchiectasis from the Spanish Registry of Bronchiectasis were included. To compare groups, the sample was divided into increasing quartiles of NLR ratio. Correlations between quantitative variables were established using Pearson's P test. A simple linear regression (with the value of exacerbations as a quantitative variable) was used to determine the independent relationship between the number and severity of exacerbations and the NLR ratio. The area under the curve (AUC)-ROC was used to determine the predictive capacity of the NLR for severe bronchiectasis, according to the different multidimensional scores. Mean age: 69 (15) years (66.3% of women). The mean NLR was 2.92 (2.03). A higher NLR was associated with more severe bronchiectasis (with an especially significant discriminative power for severe forms) according to the commonly used scores (FACED, E-FACED and BSI), as well as with poorer quality of life (SGRQ), more comorbidities (Charlson index), infection by pathogenic microorganisms, and greater application of treatment. Furthermore, the NLR correlated better with severity scores than other parameters of systemic inflammation. Finally, it was an independent predictor of the incident number and severity of exacerbations. In conclusion, the NLR is an inexpensive and easy-to-measure marker of systemic inflammation for determining severity and predicting exacerbations (especially the most severe) in patients with bronchiectasis.
- dc.format.mimetype application/pdf
- dc.identifier.citation Martinez-García MÁ, Olveira C, Girón R, García-Clemente M, Máiz-Carro L, Sibila O, Golpe R, et al. Peripheral neutrophil-to-lymphocyte ratio in bronchiectasis. A marker of disease severity. Biomolecules. 2022 Sep 30; 12(10): 1399. DOI: 10.3390/biom12101399
- dc.identifier.doi http://dx.doi.org/10.3390/biom12101399
- dc.identifier.issn 2218-273X
- dc.identifier.uri http://hdl.handle.net/10230/55894
- dc.language.iso eng
- dc.publisher MDPI
- dc.rights © [AAAA] by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Bronchiectasis
- dc.subject.keyword Exacerbations
- dc.subject.keyword Lymphocyte
- dc.subject.keyword Neutrophil
- dc.subject.keyword Severity
- dc.title Peripheral neutrophil-to-lymphocyte ratio in bronchiectasis. A marker of disease severity
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion