Evolution of early development in dipterans: reverse-engineering the gap gene network in the moth midge Clogmia albipunctata (Psychodidae)

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  • dc.contributor.author Crombach, Anton
  • dc.contributor.author García-Solache, Mónica A.
  • dc.contributor.author Jaeger, Johannes, 1973-
  • dc.date.accessioned 2023-12-11T06:48:02Z
  • dc.date.available 2023-12-11T06:48:02Z
  • dc.date.issued 2014
  • dc.description Includes supplemental materials for the online appendix.
  • dc.description.abstract Understanding the developmental and evolutionary dynamics of regulatory networks is essential if we are to explain the non-random distribution of phenotypes among the diversity of organismic forms. Here, we present a comparative analysis of one of the best understood developmental gene regulatory networks today: the gap gene network involved in early patterning of insect embryos. We use gene circuit models, which are fitted to quantitative spatio-temporal gene expression data for the four trunk gap genes hunchback (hb), Krüppel (Kr), giant (gt), and knirps (kni)/knirps-like (knl) in the moth midge Clogmia albipunctata, and compare them to equivalent reverse-engineered circuits from our reference species, the vinegar fly Drosophila melanogaster. In contrast to the single network structure we find for D. melanogaster, our models predict four alternative networks for C. albipunctata. These networks share a core structure, which includes the central regulatory feedback between hb and knl. Other interactions are only partially determined, as they differ between our four network structures. Nevertheless, our models make testable predictions and enable us to gain specific insights into gap gene regulation in C. albipunctata. They suggest a less central role for Kr in C. albipunctata than in D. melanogaster, and show that the mechanisms causing an anterior shift of gap domains over time are largely conserved between the two species, although shift dynamics differ. The set of C. albipunctata gene circuit models presented here will be used as the starting point for data-constrained in silico evolutionary simulations to study patterning transitions in the early development of dipteran species.
  • dc.description.sponsorship The laboratory of Johannes Jaeger and this study in particular was funded by the MEC-EMBL agreement for the EMBL/CRG Research Unit in Systems Biology, by SGR Grant 406 from the Catalan funding agency AGAUR, by grants BFU2009-10184 and BFU2012-33775 from the Spanish Ministry of Science (MICINN, now called MINECO), and by European Commission grant FP7-KBBE-2011-5/289434 (BioPreDyn). Early stages of this work were funded by a Conacyt scholarship to MG-S, and by BBSRC grant no. BB/D000513/1 supporting JJ. The Centre for Genomic Regulation (CRG) acknowledges support from the Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013-2017’, SEV-2012-0208.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Crombach A, García-Solache MA, Jaeger J. Evolution of early development in dipterans: reverse-engineering the gap gene network in the moth midge Clogmia albipunctata (Psychodidae). Biosystems. 2014 Sep;123:74-85. DOI: 10.1016/j.biosystems.2014.06.003
  • dc.identifier.doi http://dx.doi.org/10.1016/j.biosystems.2014.06.003
  • dc.identifier.issn 0303-2647
  • dc.identifier.uri http://hdl.handle.net/10230/58486
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Biosystems. 2014 Sep;123:74-85
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/289434
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-10184
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-33775
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SEV-2012-0208
  • dc.rights © 2014 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/3.0/
  • dc.subject.keyword Clogmia albipunctata
  • dc.subject.keyword Drosophila melanogaster
  • dc.subject.keyword Evolutionary developmental biology
  • dc.subject.keyword Gap gene network
  • dc.subject.keyword Network evolution
  • dc.subject.keyword Reverse-engineering
  • dc.title Evolution of early development in dipterans: reverse-engineering the gap gene network in the moth midge Clogmia albipunctata (Psychodidae)
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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