The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS

Orkin, Joseph D.; Manuel Montero, Marc de, 1991-; Campo, Javier del; Fontseré Alemany, Clàudia, 1992-; Kuderna, Lukas, 1989-; Lizano González, Esther, 1974-; Marquès i Bonet, Tomàs, 1975-; Melin, Amanda D.

The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS

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dc.contributor.author Orkin, Joseph D.
dc.contributor.author Manuel Montero, Marc de, 1991-
dc.contributor.author Campo, Javier del
dc.contributor.author Fontseré Alemany, Clàudia, 1992-
dc.contributor.author Kuderna, Lukas, 1989-
dc.contributor.author Lizano González, Esther, 1974-
dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author Melin, Amanda D.
dc.date.accessioned 2021-03-11T07:09:36Z
dc.date.available 2021-03-11T07:09:36Z
dc.date.issued 2021
dc.description.abstract Ecological flexibility, extended lifespans, and large brains have long intrigued evolutionary biologists, and comparative genomics offers an efficient and effective tool for generating new insights into the evolution of such traits. Studies of capuchin monkeys are particularly well situated to shed light on the selective pressures and genetic underpinnings of local adaptation to diverse habitats, longevity, and brain development. Distributed widely across Central and South America, they are inventive and extractive foragers, known for their sensorimotor intelligence. Capuchins have among the largest relative brain size of any monkey and a lifespan that exceeds 50 y, despite their small (3 to 5 kg) body size. We assemble and annotate a de novo reference genome for Cebus imitator Through high-depth sequencing of DNA derived from blood, various tissues, and feces via fluorescence-activated cell sorting (fecalFACS) to isolate monkey epithelial cells, we compared genomes of capuchin populations from tropical dry forests and lowland rainforests and identified population divergence in genes involved in water balance, kidney function, and metabolism. Through a comparative genomics approach spanning a wide diversity of mammals, we identified genes under positive selection associated with longevity and brain development. Additionally, we provide a technological advancement in the use of noninvasive genomics for studies of free-ranging mammals. Our intra- and interspecific comparative study of capuchin genomics provides insights into processes underlying local adaptation to diverse and physiologically challenging environments, as well as the molecular basis of brain evolution and longevity.
dc.description.sponsorship Funding was provided by Washington University in St. Louis, the Canada Research Chairs Program, and a National Sciences and Engineering Research Council of Canada Discovery Grant (to A.D.M.); the Alberta Children’s Hospital Research Institute (A.D.M., J.D.O., and M.C.J.); the Beatriu de Pinós postdoctoral programme of the Government of Catalonia’s Secretariat for Universities and Research of the Ministry of Economy and Knowledge 2017 BP 00265 (to J.D.O.); and the Japan Society for the Promotion of Science 15H02421 and 18H04005 (to S.K.). This work was partly funded by a Methuselah Foundation grant (to J.P.d.M.); and the Comisión Nacional de Investigación Científica y Tecnológica Chile through the doctoral studentship number 21170433 and the scholarship from the Higher Education Quality Improvement Program (MECESUP) AUS 2003 (to D.T.-M.). GenAge is funded by a Biotechnology and Biological Sciences Research Council Grant BB/R014949/1 (to J.P.d.M.). T.M.-B. is supported by funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 864203), BFU2017-86471-P (MINECO/FEDER, UE), “Unidad de Excelencia María de Maeztu”, funded by the Agencia Estatal de Investigación (CEX2018-000792-M), Howard Hughes International Early Career, Obra Social “La Caixa” and Secretaria d’Universitats i Recerca and CERCA Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880). C.F. is supported by the “La Caixa” doctoral fellowship program. E.L. is supported by CGL2017-82654-P (MINECO/FEDER, UE). M.C.J. is supported by funding from the Natural Environment Research Council (NE/T000341/1). The funding bodies played no role in the design of the study, in the collection, analysis, and interpretation of data, or in writing the report.
dc.format.mimetype application/pdf
dc.identifier.citation Orkin JD, Montague MJ, Tejada-Martinez D, de Manuel M, Del Campo J, Cheves Hernandez S et al. The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS. Proc Natl Acad Sci U S A. 2021; 118(7):e2010632118. DOI: 10.1073/pnas.2010632118
dc.identifier.doi http://dx.doi.org/10.1073/pnas.2010632118
dc.identifier.issn 0027-8424
dc.identifier.uri http://hdl.handle.net/10230/46724
dc.language.iso eng
dc.publisher National Academy of Sciences
dc.relation.ispartof Proc Natl Acad Sci U S A. 2021; 118(7):e2010632118
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/864203
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-86471-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CGL2017-82654-P
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword Brain size
dc.subject.keyword Flow cytometry
dc.subject.keyword Longevity
dc.subject.keyword Noninvasive genomics
dc.subject.keyword Seasonality
dc.title The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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