The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila
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- dc.contributor.author Molnar, Cristina
- dc.contributor.author Heinen, Jan Peter
- dc.contributor.author Reina, José
- dc.contributor.author Llamazares, Salud
- dc.contributor.author Palumbo, Emilio
- dc.contributor.author Breschi, Alessandra, 1988-
- dc.contributor.author Gay, Marina
- dc.contributor.author Villarreal, Laura
- dc.contributor.author Vilaseca, Marta
- dc.contributor.author Pollarolo, Giulia
- dc.contributor.author González, Cayetano
- dc.date.accessioned 2019-10-28T13:35:50Z
- dc.date.available 2019-10-28T13:35:50Z
- dc.date.issued 2019
- dc.description.abstract The notable male predominance across many human cancer types remains unexplained. Here, we show that Drosophila l(3)mbt brain tumors are more invasive and develop as malignant neoplasms more often in males than in females. By quantitative proteomics, we have identified a signature of proteins that are differentially expressed between male and female tumor samples. Prominent among them is the conserved chromatin reader PHD finger protein 7 (Phf7). We show that Phf7 depletion reduces sex-dependent differences in gene expression and suppresses the enhanced malignant traits of male tumors. Our results identify potential regulators of sex-linked tumor dimorphism and show that these genes may serve as targets to suppress sex-linked malignant traits.
- dc.description.sponsorship Part of this study was funded by ERC AdG 2011 294603 and BFU2015-66304-P from the MINECO, Spain.
- dc.format.mimetype application/pdf
- dc.identifier.citation Molnar C, Heinen JP, Reina J, Llamazares S, Palumbo E, Breschi A et al. The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila. Sci Adv. 2019;5(8):eaaw7965. DOI: 10.1126/sciadv.aaw7965
- dc.identifier.doi http://dx.doi.org/10.1126/sciadv.aaw7965
- dc.identifier.issn 2375-2548
- dc.identifier.uri http://hdl.handle.net/10230/42532
- dc.language.iso eng
- dc.publisher American Association for the Advancement of Science (AAAS)
- dc.relation.ispartof Science Advances. 2019;5(8):eaaw7965
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/294603
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-66304-P
- dc.rights Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.title The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion