A longitudinal study of free leptin index in pre-eclamptic pregnancies

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• dc.contributor.author Garcés, María Fernanda
• dc.contributor.author Buell-Acosta, Julieth Daniela
• dc.contributor.author Rodríguez-Navarro, Haiver Antonio
• dc.contributor.author Páez-Leal, María Carolina
• dc.contributor.author Maldonado-Acosta, Luis Miguel
• dc.contributor.author Peralta-Franco, Jhon Jairo
• dc.contributor.author Burgos-Cardenas, Álvaro Javier
• dc.contributor.author Ángel-Müller, Edith
• dc.contributor.author Parada-Baños, Arturo José
• dc.contributor.author Parra-Pineda, Mario Orlando
• dc.contributor.author Eslava-Schmalbach, Javier
• dc.contributor.author Escobar-Sarmiento, Camilo Andrés
• dc.contributor.author Lacunza, Ezequiel
• dc.contributor.author Caminos-Cepeda, Sofia Alexandra
• dc.contributor.author Castaño, Justo P.
• dc.contributor.author Nogueiras, Ruben
• dc.contributor.author Dieguez, Carlos
• dc.contributor.author Ruiz-Parra, Ariel Iván
• dc.contributor.author Caminos, Jorge Eduardo
• dc.date.accessioned 2023-09-20T06:51:47Z
• dc.date.available 2023-09-20T06:51:47Z
• dc.date.issued 2023
• dc.description.abstract The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre-eclamptic pregnancies in a nested case-control study within a prospective observational study. Circulating levels of leptin and sOB-R levels rise significantly during pregnancy in healthy (p < 0.05) (n = 46) and pre-eclamptic pregnancies (p < 0.05) (n = 20). Serum levels of leptin were significantly higher in pre-eclamptic compared to healthy pregnancies at second and third trimesters of pregnancy (p < 0.05). Additionally, serum levels of sOB-R were significantly lower in pre-eclamptic pregnancies during the second and third trimesters of pregnancy compared to healthy pregnancies (p < 0.05). Moreover, we found that FLI did not vary significantly during pregnancy in healthy women (p > 0.05), while it increases in pre-eclamptic pregnancies (p < 0.05). Indeed, FLI was significantly higher at second and third trimesters of pregnancy in pre-eclamptic compared to healthy pregnancies (p < 0.05). In addition, FLI was significantly higher in the luteal phase compared with the follicular phase of the menstrual cycle in eumenorrheic women (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed the ability of leptin (AUC = 0.72) and FLI (AUC = 0.67) as a reliable predictor for mild pre-eclampsia during the second trimester of pregnancy. In conclusion, our findings show that FLI were significantly increased in mild pre-eclamptic pregnancies and allowed us to hypothesize that this rise might alter leptin bioavailability and bioactivity which might lead to the sympathetic hyperactivity and the hypertensive disorders during pregnancy.
• dc.description.sponsorship This study was supported by government grants to the Universidad Nacional de Colombia (DIEB) and School of Medicine (código Hermes: 41439) and Ministerio de Ciencia, Tecnología e Innovación (Minciencias) (CD: 202010012913-2019-INV-Colciencias). Additionally, this work was supported by grants from FEDER/Ministerio de Ciencia, Innovación y Universidades-Agencia Estatal de Investigación (CD: BFU2017-87721; RN: RTI2018-099413-B-I00); Xunta de Galicia (RN: 2021-CP085 and 2020-PG0157).
• dc.format.mimetype application/pdf
• dc.identifier.citation Garcés MF, Buell-Acosta JD, Rodríguez-Navarro HA, Páez-Leal MC, Maldonado-Acosta LM, Peralta-Franco JJ, Burgos-Cardenas ÁJ, Ángel-Müller E, Parada-Baños AJ, Parra-Pineda MO, Eslava-Schmalbach J, Escobar-Sarmiento CA, Lacunza E, Caminos-Cepeda SA, Castaño JP, Nogueiras R, Dieguez C, Ruiz-Parra AI, Caminos JE. A longitudinal study of free leptin index in pre-eclamptic pregnancies. J Cell Mol Med. 2023;27(8):1083-94. DOI: 10.1111/jcmm.17707
• dc.identifier.doi http://dx.doi.org/10.1111/jcmm.17707
• dc.identifier.issn 1582-1838
• dc.identifier.uri http://hdl.handle.net/10230/57920
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof J Cell Mol Med. 2023;27(8):1083-94
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-099413-B-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-87721
• dc.rights © 2023 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Free leptin index
• dc.subject.keyword Pregnancy and pre-eclampsia
• dc.title A longitudinal study of free leptin index in pre-eclamptic pregnancies
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion