Early life origins of lung ageing: early life exposures and lung function decline in adulthood in two european cohorts aged 28-73 years

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  • dc.contributor.author Dratva, Juliaca
  • dc.contributor.author Zemp, Elisabethca
  • dc.contributor.author Dharmage, Shyamali C.ca
  • dc.contributor.author Accordini, Simoneca
  • dc.contributor.author Burdet, Lucca
  • dc.contributor.author Gislason, Thorarinnca
  • dc.contributor.author Heinrich, Joachimca
  • dc.contributor.author Janson, Christerca
  • dc.contributor.author Jarvis, Deborahca
  • dc.contributor.author Marco, Roberto deca
  • dc.contributor.author Norbäck, Danca
  • dc.contributor.author Pons, Marcoca
  • dc.contributor.author Gómez Real, Franciscoca
  • dc.contributor.author Sunyer Deu, Jordica
  • dc.contributor.author Villani, Simonaca
  • dc.contributor.author Probst-Hensch, Nicoleca
  • dc.contributor.author Svanes, Cecilieca
  • dc.date.accessioned 2016-04-18T12:23:29Z
  • dc.date.available 2016-04-18T12:23:29Z
  • dc.date.issued 2016
  • dc.description.abstract OBJECTIVES: Early life environment is essential for lung growth and maximally attained lung function. Whether early life exposures impact on lung function decline in adulthood, an indicator of lung ageing, has scarcely been studied. METHODS: Spirometry data from two time points (follow-up time 9-11 years) and information on early life exposures, health and life-style were available from 12862 persons aged 28-73 years participating in the European population-based cohorts SAPALDIA (n = 5705) and ECRHS (n = 7157). The associations of early life exposures with lung function (FEV1) decline were analysed using mixed-effects linear regression. RESULTS: Early life exposures were significantly associated with FEV1 decline, with estimates almost as large as personal smoking. FEV1 declined more rapidly among subjects born during the winter season (adjusted difference in FEV1/year of follow-up [95%CI] -2.04ml [-3.29;-0.80]), of older mothers, (-1.82 ml [-3.14;-0.49]) of smoking mothers (-1.82ml [-3.30;-0.34] or with younger siblings (-2.61ml [-3.85;-1.38]). Less rapid FEV1-decline was found in subjects who had attended daycare (3.98ml [2.78;5.18]), and indicated in subjects with pets in childhood (0.97ml [-0.16;2.09]). High maternal age and maternal smoking appeared to potentiate effects of personal smoking. The effects were independent of asthma at any age. CONCLUSION: Early life factors predicted lung function decline decades later, suggesting that some mechanisms related lung ageing may be established early in life. Early life programming of susceptibility to adult insults could be a possible pathway that should be explored further.ca
  • dc.description.sponsorship The first author was supported by a Marie Heim-Vögtlin grant from the Swiss National Science Foundation (grant # PMPDP3_129021/1; # PMPDP3_141671/1), the Lung league Beider Basel, Lung league Graubünden, the Stiftung ehemals Bündner Heilstätten and the COST action BM1201. Research support received by the SAPALDIA and ECRHS cohorts can be found in the online supplement (e-supplement).
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Dratva J, Zemp E, Dharmage SC, Accordini S, Burdet L, Gislason T et al. Early life origins of lung ageing: early life /n/nexposures and lung function decline in adulthood in two european cohorts aged 28-73 years. PLoS One. 2016; 11(1): /n/ne0145127. DOI 10.1371/journal.pone.0145127ca
  • dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0145127
  • dc.identifier.issn 1932-6203
  • dc.identifier.uri http://hdl.handle.net/10230/26112
  • dc.language.iso engca
  • dc.publisher Public Library of Science (PLoS)ca
  • dc.relation.ispartof PLoS One. 2016; 11(1): e0145127
  • dc.rights © 2016 Dratva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
  • dc.subject.other Pulmons -- Metabolismeca
  • dc.title Early life origins of lung ageing: early life exposures and lung function decline in adulthood in two european cohorts aged 28-73 yearsca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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