Air pollution, white matter microstructure, and brain volumes: Periods of susceptibility from pregnancy to preadolescence

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• dc.contributor.author Binter, Anne-Claire
• dc.contributor.author Kusters, Michelle S.W.
• dc.contributor.author van den Dries, Michiel
• dc.contributor.author Alonso, Lucia
• dc.contributor.author Lubczyńska, Małgorzata Joanna, 1984-
• dc.contributor.author Hoek, Gerard
• dc.contributor.author White, Tonya
• dc.contributor.author Iñiguez, Carmen
• dc.contributor.author Tiemeier, Henning
• dc.contributor.author Guxens Junyent, Mònica
• dc.date.accessioned 2023-02-28T07:15:22Z
• dc.date.available 2023-02-28T07:15:22Z
• dc.date.issued 2022
• dc.description.abstract Air pollution exposure during early-life is associated with altered brain development, but the precise periods of susceptibility are unknown. We aimed to investigate whether there are periods of susceptibility of air pollution between conception and preadolescence in relation to white matter microstructure and brain volumes at 9-12 years old. We used data of 3515 children from the Generation R Study, a population-based birth cohort from Rotterdam, the Netherlands (2002-2006). We estimated daily levels of nitrogen dioxide (NO2), and particulate matter (PM2.5 and PM2.5absorbance) at participants' homes during pregnancy and childhood using land-use regression models. Diffusion tensor and structural brain images were obtained when children were 9-12 years of age, and we calculated fractional anisotropy and mean diffusivity, and several brain structure volumes. We performed distributed lag non-linear modeling adjusting for socioeconomic and lifestyle characteristics. We observed specific periods of susceptibility to all air pollutants from conception to age 5 years in association with lower fractional anisotropy and higher mean diffusivity that survived correction for multiple testing (e.g., -0.85 fractional anisotropy (95%CI -1.43; -0.27) per 5 μg/m3 increase in PM2.5 between conception and 4 years of age). We also observed certain periods of susceptibility to some air pollutants in relation to global brain and some subcortical brain volumes, but only the association between PM2.5 and putamen survived correction for multiple testing (172 mm3 (95%CI 57; 286) per 5 μg/m3 increase in PM2.5 between 4 months and 1.8 year of age). This study suggested that conception, pregnancy, infancy, toddlerhood, and early childhood seem to be susceptible periods to air pollution exposure for the development of white matter microstructure and the putamen volume. Longitudinal studies with repeated brain outcome measurements are needed for understanding the trajectories and the long-term effects of exposure to air pollution.
• dc.description.sponsorship The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam, Rotterdam; the Municipal Health Service Rotterdam Area, Rotterdam; the Rotterdam Homecare Foundation, Rotterdam; and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR-MDC), Rotterdam. The general design of the Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam; the Erasmus University Rotterdam; Netherlands Organization for Health Research and Development (ZonMw); the Netherlands Organization for Scientific Research (NWO); and the Ministry of Health, Welfare and Sport. Air pollution exposure assessment was made possible by funding from the European Community's Seventh Framework Program (Grant Agreement no. 211250, Grant Agreement no. 243406). In addition, the study was made possible by financial support from the ZonMw (Geestkracht Program 10.000.1003 and TOP 40-00812-98-11021). Supercomputing resources for neuroimaging data processing were provided by the Dutch Organization for Scientific Research (NWO, Cartesius/Snellius). Research described in this article was conducted under contract to the HEI, an organization jointly funded by the U.S. EPA (Assistance Award No. R-82811201) and certain motor vehicle and engine manufacturers. The contents of this article do not necessarily reflect the views of HEI, or its sponsors, nor do they necessarily reflect the views and policies of the U.S. EPA or motor vehicle and engine manufacturers. M.G. is funded by a Miguel Servet fellowship (CPII18/00018) awarded by the Spanish Institute of Health Carlos III. We acknowledge support from the Spanish Ministry of Science and Innovation and State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX 2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. This study was co-financed by the Agencia Estatal de Investigación (AEI) and the European Social Fund (FSE) " EL FSE invierte en tu futuro” with reference number PRE2020-092005, according to the Resolution of the Presidency of the AEI, by which grants are awarded for pre-doctoral contracts for the training of doctors, call 2020 (awarded to M.S.W.K).
• dc.format.mimetype application/pdf
• dc.identifier.citation Binter AC, Kusters MSW, van den Dries MA, Alonso L, Lubczyńska MJ, Hoek G, White T, Iñiguez C, Tiemeier H, Guxens M. Air pollution, white matter microstructure, and brain volumes: Periods of susceptibility from pregnancy to preadolescence. Environ Pollut. 2022 Nov 15;313:120109. DOI: 10.1016/j.envpol.2022.120109
• dc.identifier.doi http://dx.doi.org/10.1016/j.envpol.2022.120109
• dc.identifier.issn 0269-7491
• dc.identifier.uri http://hdl.handle.net/10230/55945
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Pollut. 2022 Nov 15;313:120109
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/243406
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
• dc.rights © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Air pollution
• dc.subject.keyword Child development
• dc.subject.keyword Cohort studies
• dc.subject.keyword Neuroimaging
• dc.subject.keyword Time series
• dc.title Air pollution, white matter microstructure, and brain volumes: Periods of susceptibility from pregnancy to preadolescence
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion