The host tRNA epitranscriptome: A new player in RNA virus infections

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• dc.contributor.author Talló Parra, Marc, 1992-
• dc.contributor.author Muscolino, Elena
• dc.contributor.author Díez Antón, Juana, 1962-
• dc.date.accessioned 2023-03-02T07:05:37Z
• dc.date.available 2023-03-02T07:05:37Z
• dc.date.issued 2022
• dc.description.abstract Viruses completely depend on the host translation machineries to express the viral proteins. Recent data reveal an unprecedented interaction of positive strand RNA ((+)RNA) viruses with the host tRNA epitranscriptome to favor viral protein expression via a specific reprogramming of codon optimality that ultimately favors decoding of the viral codons. We propose that this feature is shared by multiple RNA viruses and that the involved tRNA modifying enzymes represent promising novel targets for the development of broad-spectrum antivirals.
• dc.description.sponsorship This work was supported by the Spanish Ministry of Economy, Industry and Competitiveness (AEI/MINECO/FEDER, UE; PID2019-106959RB-I00) and the “Unidad de Excelencia María de Maeztu” funded by the AEI (CEX2018-000792-M).
• dc.format.mimetype application/pdf
• dc.identifier.citation Talló-Parra M, Muscolino E, Díez J. The host tRNA epitranscriptome: A new player in RNA virus infections. Front Virol. 2022;2:1073619. DOI: 10.3389/fviro.2022.1073619
• dc.identifier.doi http://dx.doi.org/10.3389/fviro.2022.1073619
• dc.identifier.issn 2673-818X
• dc.identifier.uri http://hdl.handle.net/10230/56009
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Front Virol. 2022;2:1073619
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-106959RB-I00
• dc.rights © 2022 Talló-Parra, Muscolino and Díez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword tRNA
• dc.subject.keyword tRNA modifications
• dc.subject.keyword tRNA epitranscriptome
• dc.subject.keyword (+)RNA viruses
• dc.subject.keyword CHIKV
• dc.subject.keyword KIAA1456
• dc.subject.keyword Viruses
• dc.subject.keyword Codon usage
• dc.title The host tRNA epitranscriptome: A new player in RNA virus infections
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion