The host tRNA epitranscriptome: A new player in RNA virus infections

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dc.contributor.authorTalló Parra, Marc, 1992-
dc.contributor.authorMuscolino, Elena
dc.contributor.authorDíez Antón, Juana, 1962-
dc.date.accessioned2023-03-02T07:05:37Z
dc.date.available2023-03-02T07:05:37Z
dc.date.issued2022
dc.description.abstractViruses completely depend on the host translation machineries to express the viral proteins. Recent data reveal an unprecedented interaction of positive strand RNA ((+)RNA) viruses with the host tRNA epitranscriptome to favor viral protein expression via a specific reprogramming of codon optimality that ultimately favors decoding of the viral codons. We propose that this feature is shared by multiple RNA viruses and that the involved tRNA modifying enzymes represent promising novel targets for the development of broad-spectrum antivirals.
dc.description.sponsorshipThis work was supported by the Spanish Ministry of Economy, Industry and Competitiveness (AEI/MINECO/FEDER, UE; PID2019-106959RB-I00) and the “Unidad de Excelencia María de Maeztu” funded by the AEI (CEX2018-000792-M).
dc.format.mimetypeapplication/pdf
dc.identifier.citationTalló-Parra M, Muscolino E, Díez J. The host tRNA epitranscriptome: A new player in RNA virus infections. Front Virol. 2022;2:1073619. DOI: 10.3389/fviro.2022.1073619
dc.identifier.doihttp://dx.doi.org/10.3389/fviro.2022.1073619
dc.identifier.issn2673-818X
dc.identifier.urihttp://hdl.handle.net/10230/56009
dc.language.isoeng
dc.publisherFrontiers
dc.relation.ispartofFront Virol. 2022;2:1073619
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2PE/PID2019-106959RB-I00
dc.rights© 2022 Talló-Parra, Muscolino and Díez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.keywordtRNA
dc.subject.keywordtRNA modifications
dc.subject.keywordtRNA epitranscriptome
dc.subject.keyword(+)RNA viruses
dc.subject.keywordCHIKV
dc.subject.keywordKIAA1456
dc.subject.keywordViruses
dc.subject.keywordCodon usage
dc.titleThe host tRNA epitranscriptome: A new player in RNA virus infections
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion

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