Hedgehog signaling governs the development of otic sensory epithelium and its associated innervation in zebrafish

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• dc.contributor.author Sapède, Doraca
• dc.contributor.author Pujades Corbi, Cristinaca
• dc.date.accessioned 2012-07-05T06:53:33Z
• dc.date.available 2012-07-05T06:53:33Z
• dc.date.issued 2010ca
• dc.description.abstract The inner ear is responsible for the perception of motion and sound in vertebrates. Its functional unit, the sensory patch, contains mechanosensory hair cells innervated by sensory neurons from the statoacoustic ganglion (SAG) that project to the corresponding nuclei in the brainstem. How hair cells develop at specific positions, and how otic neurons are sorted to specifically innervate each endorgan and to convey the extracted information to the hindbrain is not completely understood. In this work, we study the generation of macular sensory patches and investigate the role of Hedgehog (Hh) signaling in the production of their neurosensory elements. Using zebrafish transgenic lines to visualize the dynamics of hair cell and neuron production, we show that the development of the anterior and posterior maculae is asynchronic, suggesting they are independently regulated. Tracing experiments demonstrate the SAG is topologically organized in two different neuronal subpopulations, which are spatially segregated and innervate specifically each macula. Functional experiments identify the Hh pathway as crucial in coordinating the production of hair cells in the posterior macula, and the formation of its specific innervation. Finally, gene expression analyses suggest that Hh influences the balance between different SAG neuronal subpopulations. These results lead to a model in which Hh orients functionally the development of inner ear towards an auditory fate in all vertebrate species.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Sapède D, Pujades C. Hedgehog signaling governs the development of otic sensory epithelium and its associated innervation in zebrafish. J. Neurosci. 2010;30(10):3612-23. DOI: 10.1523/JNEUROSCI.5109-09.2010ca
• dc.identifier.doi http://dx.doi.org/10.1523/JNEUROSCI.5109-09.2010
• dc.identifier.issn 0270-6474ca
• dc.identifier.uri http://hdl.handle.net/10230/16654
• dc.language.iso engca
• dc.publisher Society for Neuroscienceca
• dc.relation.ispartof Journal of Neuroscience. 2010;30(10):3612-23
• dc.rights © 2010, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/30/10/3612ca
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Laberint (Orella) -- Fisiologia
• dc.subject.other Laberint (Orella) -- Fisiologia
• dc.subject.other Neurobiologia del desenvolupament
• dc.title Hedgehog signaling governs the development of otic sensory epithelium and its associated innervation in zebrafishca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersion