Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of down syndrome.

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  • dc.contributor.author Catuara Solarz, Silvina, 1986-ca
  • dc.contributor.author Espinosa-Carrasco, Joséca
  • dc.contributor.author Erb, Ionasca
  • dc.contributor.author Langohr, Klausca
  • dc.contributor.author Notredame, Cedricca
  • dc.contributor.author González Ruiz, Juan Ramónca
  • dc.contributor.author Dierssen, Maraca
  • dc.date.accessioned 2016-02-04T12:14:07Z
  • dc.date.available 2016-02-04T12:14:07Z
  • dc.date.issued 2015
  • dc.description.abstract Down syndrome (DS) individuals present increased risk for Alzheimer's disease (AD) neuropathology and AD-type dementia. Here, we investigated the use of green tea extracts containing (-)-epigallocatechin-3-gallate (EGCG), as co-adjuvant to enhance the effects of environmental enrichment (EE) in Ts65Dn mice, a segmental trisomy model of DS that partially mimics DS/AD pathology, at the age of initiation of cognitive decline. Classical repeated measures ANOVA showed that combined EE-EGCG treatment was more efficient than EE or EGCG alone to improve specific spatial learning related variables. Using principal component analysis (PCA) we found that several spatial learning parameters contributed similarly to a first PC and explained a large proportion of the variance among groups, thus representing a composite learning measure. This PC1 revealed that EGCG or EE alone had no significant effect. However, combined EE-EGCG significantly ameliorated learning alterations of middle age Ts65Dn mice. Interestingly, PCA revealed an increased variability along learning sessions with good and poor learners in Ts65Dn, and this stratification did not disappear upon treatments. Our results suggest that combining EE and EGCG represents a viable therapeutic approach for amelioration of age-related cognitive decline in DS, although its efficacy may vary across individuals.ca
  • dc.description.sponsorship The laboratory of Mara Dierssen is supported by DIUE de la Generalitat de Catalunya (Grups consolidats SGR 2014/1125). This work was supported by Fondation Jérôme Lejeune (Paris, France), MINECO (SAF2013-49129-C2-1-R), CDTI (“Smartfoods”), and EU (Era Net Neuron PCIN-2013-060). The CRG is a Center of Excellence Severo Ochoa SEV-2012-0208. The CIBER of Rare Diseases is an initiative of the ISCIII. The laboratory of Cedric Notredame acknowledges the funding from the Spanish Ministry of Economy and Finance (MINECO), grant number BFU2011-28575. Silvina Catuara-Solarz received a FPI doctoral fellowship from Spanish Ministry of Economy and Finance (MINECO), SAF2010-16427; Jose Espinosa-Carrasco received the FI grant from Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) de la Generalitat de Catalunya.
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Catuara-Solarz S, Espinosa-Carrasco J, Erb I, Langohr K, Notredame C, Gonzalez JR. et al. Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of down syndrome. Front Behav Neurosci. 2015 Dec 11;9:330. DOI: 10.3389/fnbeh.2015.00330ca
  • dc.identifier.doi http://dx.doi.org/10.3389/fnbeh.2015.00330
  • dc.identifier.issn 1662-5153
  • dc.identifier.uri http://hdl.handle.net/10230/25732
  • dc.language.iso engca
  • dc.publisher Frontiersca
  • dc.relation.ispartof Frontiers in Behavioral Neuroscience. 2015 Dec 11;9:330
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-16427
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-49129-C2-1-R
  • dc.rights © 2015 Catuara-Solarz, Espinosa-Carrasco, Erb, Langohr, Notredame, Gonzalez and Dierssen. This is an open-access article distributed under the terms of http://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
  • dc.subject.other Down, Síndrome deca
  • dc.subject.other Alzheimer, Malaltia d'ca
  • dc.title Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of down syndrome.ca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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