Early life tobacco exposure and children's telomere length: The HELIX project

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• dc.contributor.author Osorio Yáñez, Citlalli
• dc.contributor.author Clemente Batalha Pardal, Diana, 1990-
• dc.contributor.author Maitre, Léa
• dc.contributor.author Vives Usano, Marta, 1990-
• dc.contributor.author Bustamante Pineda, Mariona
• dc.contributor.author Martínez, David
• dc.contributor.author Casas Sanahuja, Maribel
• dc.contributor.author Urquiza, José M.
• dc.contributor.author Tamayo-Uria, Ibon
• dc.contributor.author Sunyer Deu, Jordi
• dc.contributor.author Vrijheid, Martine
• dc.date.accessioned 2023-11-21T06:39:53Z
• dc.date.available 2023-11-21T06:39:53Z
• dc.date.issued 2020
• dc.description.abstract Telomere length and mitochondrial DNA content are considered biomarkers of cellular aging, oxidative stress, and inflammation, but there is almost no information on their association with tobacco smoke exposure in fetal and early life. The aim of this study was to assess whether prenatal and childhood tobacco exposure were associated with leukocyte telomere length (LTL) and mitochondrial DNA (mtDNA) content in children. As part of a multi-centre European birth cohort study HELIX (Human Early-Life Exposome) (n = 1396) we assessed maternal smoking status during pregnancy through questionnaires, and through urinary cotinine levels that were then used to classify women as not exposed to smoking (<10 µg/L), exposed to secondhand smoke (SHS) (10-50 µg/L) and active smokers (>50 µg/L). When the children were around 8 years of age (range: 5.4-12.0 years), childhood SHS tobacco smoke exposure was assessed through an extensive questionnaire and through measurements of urinary cotinine (<3.03 µg/L non-detected, >3.03 µg/L detected). Leukocyte mtDNA content and LTL were measured in the children at 8 years employing real time polymerase chain reaction (qPCR). Effect estimates were calculated using multivariate linear regression models for prenatal and childhood exposures adjusted for potential confounders. Maternal cotinine levels indicative of SHS exposure during pregnancy were associated with a decrease of 3.90% in LTL in children (95% CI: -6.68, -0.91), compared with non-smoking, whereas the association for maternal cotinine levels indicative of active smoking did not reach statistical significance (-3.24%; 95% CI: -6.59, 0.21). Childhood SHS tobacco exposure was not associated with LTL in children. Global SHS exposure during childhood was associated with an increase of 3.51% (95% CI: 0.78, 6.27) in mtDNA content. Our findings suggest that tobacco smoke exposure during pregnancy, even at SHS levels, may accelerate telomere shortening in children and thus induce biological aging from an early age.
• dc.description.sponsorship The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement no 308333 – the HELIX project. The Norwegian Mother and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research, NIH/NIEHS (contract no N01-ES-75558), NIH/NINDS (grant no. 1 UO1 NS 047537-01 and grant no. 2 UO1 NS 047537-06A1). COY was financially supported by Secretary of Science, Technology and Innovation (SECITI-DF; Mexico; Grant No BP15-001). The telomere and mtDNA protocol were developed with grants from FWO (FWO G073315N) and European research council (ERC-2012-StG 310898). Telomere measurements in the INMA cohort were partly funded by a grant grants from Instituto de Salud Carlos III (FIS-PI15/00118).
• dc.format.mimetype application/pdf
• dc.identifier.citation Osorio-Yáñez C, Clemente DBP, Maitre L, Vives-Usano M, Bustamante M, Martinez D, et al. Early life tobacco exposure and children's telomere length: The HELIX project. Sci Total Environ. 2020;711:135028. DOI: 10.1016/j.scitotenv.2019.135028
• dc.identifier.doi http://dx.doi.org/10.1016/j.scitotenv.2019.135028
• dc.identifier.issn 0048-9697
• dc.identifier.uri http://hdl.handle.net/10230/58323
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Sci Total Environ. 2020;711:135028
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/310898
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.scitotenv.2019.135028
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword HELIX
• dc.subject.keyword Leukocyte telomere length
• dc.subject.keyword Mitochondrial DNA content
• dc.subject.keyword Pregnancy
• dc.subject.keyword Tobacco exposure
• dc.title Early life tobacco exposure and children's telomere length: The HELIX project
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion