Toenail concentrations of trace elements and occupational history in pancreatic cancer
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- dc.contributor.author Camargo, Judit
- dc.contributor.author Pumarega Rodríguez, José Antonio
- dc.contributor.author Alguacil Ojeda, Juan
- dc.contributor.author Sanz-Gallén, Pere
- dc.contributor.author Gasull Panadès, Magda
- dc.contributor.author Delclos, George L.
- dc.contributor.author Amaral, André F.S.
- dc.contributor.author Porta Serra, Miquel
- dc.date.accessioned 2019-12-11T09:12:44Z
- dc.date.available 2019-12-11T09:12:44Z
- dc.date.issued 2019
- dc.description.abstract Background: Some occupations potentially entailing exposure to cadmium, arsenic, lead, selenium, nickel, and chromium have been associated with an increased risk of exocrine pancreatic cancer (EPC), but no studies have assessed whether body concentrations of such compounds differed among subjects occupationally exposed and unexposed. No studies which found that exposure to such metals increased the risk of EPC assessed whether past occupations were the source of exposure. Objective: The aim was to analyse the relationship between toenail concentrations of trace elements and occupational history in EPC patients. Methods: The study included 114 EPC cases personally interviewed on occupational history and lifestyle factors. Occupations were coded according to the International Standard Classification of Occupations 1988. Selected occupational exposures were assessed by two industrial hygienists and with the Finnish job-exposure matrix (Finjem). Concentrations of 12 trace elements were determined in toenail samples by inductively coupled plasma mass spectrometry. Adjusted geometric means (aGMs) and 95% confidence intervals (95% CI) were calculated. Results: Patients occupationally exposed to aromatic hydrocarbon solvents (AHs) had higher concentrations of cadmium, manganese, lead, iron and vanadium. The aGM of cadmium concentrations for cases exposed to any pesticide was 0.056 μg/g [95% CI: 0.029-0.108], and, for unexposed cases, 0.023 μg/g [0.017-0.031]. Patients occupationally exposed to pesticides had higher concentrations of cadmium and manganese. Higher concentrations of vanadium, lead and arsenic were related to exposure to formaldehyde. Vanadium and lead were also associated with exposure to chlorinated hydrocarbon solvents, and arsenic was related to exposure to polycyclic aromatic hydrocarbons (PAHs). Conclusions: Patients occupationally exposed to AHs, pesticides, chlorinated hydrocarbon solvents, formaldehyde, volatile sulphur compounds and PAHs had higher concentrations of several metals. These elements may account for some of the occupational risks previously reported for pancreatic cancer.
- dc.format.mimetype application/pdf
- dc.identifier.citation Camargo J, Pumarega JA, Alguacil J, Sanz-Gallén P, Gasull M, Delclos GL et al. Toenail concentrations of trace elements and occupational history in pancreatic cancer. Environ Int. 2019 Jun;127:216-25. DOI: 10.1016/j.envint.2019.03.037
- dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2019.03.037
- dc.identifier.issn 0160-4120
- dc.identifier.uri http://hdl.handle.net/10230/43137
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Environment International. 2019 Jun;127:216-25
- dc.rights 0160-4120/ © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/BY-NC-ND/4.0/
- dc.subject.keyword Arsenic
- dc.subject.keyword Cadmium
- dc.subject.keyword Manganese
- dc.subject.keyword Occupation
- dc.subject.keyword Pancreatic cancer
- dc.subject.keyword Trace elements
- dc.title Toenail concentrations of trace elements and occupational history in pancreatic cancer
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion