Multicenter study of parenteral nutrition in non-critically ill elderly patients compared to younger patients - Study IAIOS-PN (Incidence and Assessment of Iatrogenesis in Older Subjects receiving Parenteral Nutrition)

Mateu de Antonio, Francisco Javier; Berlana, David; Pons-Busom, Montserrat; Badia-Tahull, Maria B.; Miana-Mena, María Teresa; Martínez-Castro, Beatriz; Sunyer-Esquerrà, Neus; Sanmartin-Suñer, Mónica; González-Valdivieso, Juan; Leiva-Badosa, Elisabet; Martínez-Bernabé, Eva; Murgadella-Sancho, Anna; Mirerachs-Aranda, Nuria; Vila-Bundó, Anna; Fernández-Morató, Jordi; Vitales-Farrero, María Teresa

Multicenter study of parenteral nutrition in non-critically ill elderly patients compared to younger patients - Study IAIOS-PN (Incidence and Assessment of Iatrogenesis in Older Subjects receiving Parenteral Nutrition)

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dc.contributor.author Mateu de Antonio, Francisco Javier
dc.contributor.author Berlana, David
dc.contributor.author Pons-Busom, Montserrat
dc.contributor.author Badia-Tahull, Maria B.
dc.contributor.author Miana-Mena, María Teresa
dc.contributor.author Martínez-Castro, Beatriz
dc.contributor.author Sunyer-Esquerrà, Neus
dc.contributor.author Sanmartin-Suñer, Mónica
dc.contributor.author González-Valdivieso, Juan
dc.contributor.author Leiva-Badosa, Elisabet
dc.contributor.author Martínez-Bernabé, Eva
dc.contributor.author Murgadella-Sancho, Anna
dc.contributor.author Mirerachs-Aranda, Nuria
dc.contributor.author Vila-Bundó, Anna
dc.contributor.author Fernández-Morató, Jordi
dc.contributor.author Vitales-Farrero, María Teresa
dc.date.accessioned 2019-09-09T07:55:19Z
dc.date.available 2019-09-09T07:55:19Z
dc.date.issued 2018
dc.description.abstract OBJECTIVE: this study assessed the incidence of hyperglycemia, hypertriglyceridemia, and liver function test (LFT) alterations among patients older and younger than 65 years receiving parenteral nutrition (PN). A secondary objective was to compare the incidence of any of these three events. MATERIAL AND METHODS: inclusion criteria were non-critically ill adult inpatients receiving PN for ≥ 7 days in 15 hospitals in Spain. Exclusion criteria were hyperglycemia, hypertriglyceridemia, LFT alterations, sepsis, shock, pancreatic/hepatobiliary surgery, renal failure, diabetes mellitus (DM) type 1, insulin-treated DM type 2, acute DM complications, or obesity prior to PN. Patients were classified into groups YOUNG (aged 35-64) and OLD (aged 65-95). RESULTS: this study recruited 200 patients. Group YOUNG included 63 (31.5%) patients and OLD, 137 (68.5%). Hyperglycemia appeared in 37 (18.5%) patients, eight (12.7%) in group YOUNG and 29 (21.2%) in group OLD (p = 0.174). Hypertriglyceridemia appeared in only one (0.7%) patient. LFT alterations appeared in 141 (70.5%) patients, 44 (69.8%) in group YOUNG and 97 (70.8%) in group OLD (p = 1.000). The model for hyperglycemia included DM type 2, previous surgical procedure, and use of hyperglycemia-inducing medications. The model for LFT alteration included previous surgical procedure, amount of lipids and amino acids, medications causing LFT alterations and a trend for age group. The model for any event included surgical procedure, DM type 2, and medications causing alterations. CONCLUSION: patients of ≥ 65 years receiving PN had similar incidences of hyperglycemia, hypertriglyceridemia, and LFT alterations as younger patients. Additionally, older patients had trends toward lower LFT alterations.
dc.format.mimetype application/pdf
dc.identifier.citation Mateu-de Antonio J, Berlana D, Pons-Bussom M, Badia-Tahull MB, Miana-Mena MT, Martínez-Castro B, et al. Multicenter study of parenteral nutrition in non-critically ill elderly patients compared to younger patients -Study IAIOS-PN (Incidence and Assessment of Iatrogenesis in Older Subjects receiving Parenteral Nutrition). Nutr Hosp. 2018 Feb 27;35(2):252-258. DOI: 10.20960/nh.1393
dc.identifier.doi http://dx.doi.org/10.20960/nh.1393
dc.identifier.issn 0212-1611
dc.identifier.uri http://hdl.handle.net/10230/42254
dc.language.iso eng
dc.publisher Arán Ediciones
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject.other Nutrició parenteral
dc.subject.other Persones grans -- Alimentació
dc.subject.other Joves -- Alimentació
dc.title Multicenter study of parenteral nutrition in non-critically ill elderly patients compared to younger patients - Study IAIOS-PN (Incidence and Assessment of Iatrogenesis in Older Subjects receiving Parenteral Nutrition)
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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