A tunable population timer in multicellular consortia

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• dc.contributor.author Toscano Ochoa, Carlos, 1985-
• dc.contributor.author García Ojalvo, Jordi
• dc.date.accessioned 2021-05-07T07:06:22Z
• dc.date.available 2021-05-07T07:06:22Z
• dc.date.issued 2021
• dc.description.abstract Processing time-dependent information requires cells to quantify the duration of past regulatory events and program the time span of future signals. At the single-cell level, timer mechanisms can be implemented with genetic circuits. However, such systems are difficult to implement in single cells due to saturation in molecular components and stochasticity in the limited intracellular space. In contrast, multicellular implementations outsource some of the components of information-processing circuits to the extracellular space, potentially escaping these constraints. Here, we develop a theoretical framework, based on trilinear coordinate representation, to study the collective behavior of populations composed of three cell types under stationary conditions. This framework reveals that distributing different processes (in our case the production, detection and degradation of a time-encoding signal) across distinct strains enables the implementation of a multicellular timer. Our analysis also shows that the circuit can be easily tunable by varying the cellular composition of the consortium.
• dc.description.sponsorship This work was supported by the Spanish Ministry of Science and Innovation and FEDER, under projects PGC2018-101251-B-I00 and FIS2017-92551-EXP, by the “Maria de Maeztu” Programme for Units of Excellence in R&D (grant CEX2018-000792-M), and by the Generalitat de Catalunya (ICREA Academia program and grant 2017 SGR 1054).
• dc.format.mimetype application/pdf
• dc.identifier.citation Toscano-Ochoa C, Garcia-Ojalvo J. A tunable population timer in multicellular consortia. iScience. 2021;24(4):102347. DOI: 10.1016/j.isci.2021.102347
• dc.identifier.doi http://dx.doi.org/10.1016/j.isci.2021.102347
• dc.identifier.issn 2589-0042
• dc.identifier.uri http://hdl.handle.net/10230/47348
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof iScience. 2021;24(4):102347
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-101251-B-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/FIS2017-92551-EXP
• dc.rights © 2021 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Bioengineering
• dc.subject.keyword Mathematical biosciences
• dc.subject.keyword Microbiology
• dc.subject.keyword Systems biology
• dc.title A tunable population timer in multicellular consortia
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion